Figure 5 from Coevolution of Atypical BRAF and KRAS Mutations in Colorectal Tumorigenesis
Woolley CE., Domingo E., Fernandez-Tajes J., Pennel KAF., Roxburgh P., Edwards J., Richman SD., Maughan TS., Kerr DJ., Soriano I., Tomlinson IPM.
mRNA expression of the EGFR ligands AREG and EREG. A, Expression of AREG and EREG is significantly increased in the distal colorectum vs. proximal colon across the INTERMPHEN (n = 119 proximal and n = 236 distal colorectum) and TCGA COADREAD (n = 18 proximal and n = 19 distal/rectal). Log2FC and significance values obtained via DESeq2 analysis (see Materials and Methods). B, Expression of EREG is significantly increased in class 3 BRAF-mutant colorectal cancers vs. class 1 in the absence of a concomitant Ras mutation (P.adj < 0.005), which may reflect the distal colorectum bias of class 3 mutations. (Created with BioRender.com.)