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Colorectal cancer (CRC) is responsible for nearly half a million deaths annually worldwide [11]. We present a series of mathematical models describing the dynamics of the intestinal epithelium and the kinetics of the molecular pathway most commonly mutated in CRC, the Wnt signalling network We also discuss how we are coupling such models to build a multiscale model of normal and aberrant guts. This will enable us to combine disparate experimental and clinical data, to investigate interactions between phenomena taking place at different levels of organisation and, eventually, to test the efficacy of new drugs on the system as a whole.

Type

Conference paper

Publication Date

2008

Volume

971

Pages

3 - 7

Keywords

DYNAMICS, MUTATIONS, DIFFERENTIATION, WHOLE-ORGAN, cell division, ADENOMA, stem cells, crypt dynamics, APC, tumour phenotype, CRYPT