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The cell's ability to sense and respond to DNA damage is critical to maintain homeostasis and prevent the development of cancer. Paradoxically, Economopoulou et al. recently reported that a DNA damage response protein, H2AX, promotes tumor growth and angiogenesis.

Original publication

DOI

10.1016/j.ccr.2009.05.004

Type

Journal article

Journal

Cancer Cell

Publication Date

02/06/2009

Volume

15

Pages

459 - 461

Keywords

Animals, Cell Hypoxia, DNA Damage, Endothelial Cells, Endothelium, Vascular, Histones, Humans, Mice, Neoplasms, Neovascularization, Pathologic