Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

PURPOSE OF REVIEW: The past couple of years have seen a flurry of publications detailing potential prognostic and predictive biomarkers for colorectal cancer. However, most studies have been underpowered and demonstrate elements of a statistical 'fishing exercise', that is the carrying out of a huge number of analyses to find a hint of importance for a particular marker. RECENT FINDINGS: Recently some well powered analyses using separate development and validation datasets and multivariate statistics have been published and these are starting to change attitudes towards such markers. SUMMARY: Although there are very limited markers in standard clinical practice, we feel that there are now some that are ready to be translated into routine use or that at least deserve some further attention and 'service assessment'.

Original publication




Journal article


Curr Opin Oncol

Publication Date





410 - 414


Antineoplastic Protocols, Biomarkers, Tumor, Chemotherapy, Adjuvant, Colorectal Neoplasms, Humans, Prognosis, Research Design