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In a recent paper in Nature, Petropoulos et al.1 report that PARP1 acts together with the replisome components TIMELESS and TIPIN to protect the genome from transcription-replication conflicts, which has important implications for the clinical use of PARP inhibitors.

Original publication

DOI

10.1016/j.molcel.2024.04.021

Type

Journal article

Journal

Mol Cell

Publication Date

16/05/2024

Volume

84

Pages

1824 - 1825

Keywords

Humans, Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors, Poly(ADP-ribose) Polymerases, Poly (ADP-Ribose) Polymerase-1, DNA Replication, DNA Repair, Transcription, Genetic