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Acetylhomotaurine was labeled with (11)C via N-acetylation with [(11)C]acetyl chloride. The synthesis yielded 48.2+/-3.8%, decay corrected to end of bombardment. The specific activity of the (radio)chemically pure product was 20.8+/-2.0 GBq/micromol at EOS. In vivo studies revealed a very fast clearance of the tracer from the blood and a uniform distribution in the different brain regions. Unfortunately, the poor passage through the blood brain barrier makes the tracer not suitable for PET studies.

Original publication

DOI

10.1016/j.nucmedbio.2003.11.001

Type

Journal article

Journal

Nucl Med Biol

Publication Date

07/2004

Volume

31

Pages

649 - 654

Keywords

Acamprosate, Alcohol Deterrents, Alcoholism, Animals, Brain, Carbon Radioisotopes, Humans, Isotope Labeling, Male, Metabolic Clearance Rate, Mice, Positron-Emission Tomography, Rabbits, Radiopharmaceuticals, Taurine, Tissue Distribution, Treatment Outcome