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Genotoxic stress triggers a myriad of cellular responses including cell cycle arrest, stimulation of DNA repair and apoptosis. A central role for the E2F-1 transcription factor in the DNA damage response pathway is gaining support. E2F-1 is phosphorylated by DNA damage responsive protein kinases, which leads to E2F-1 accumulation and the induction of apoptosis. In addition, emerging information suggests that E2F-1 may play a role in the detection and subsequent repair of damaged DNA.

Original publication

DOI

10.1016/j.dnarep.2004.03.034

Type

Journal article

Journal

DNA Repair (Amst)

Publication Date

08/2004

Volume

3

Pages

1071 - 1079

Keywords

Animals, Apoptosis, Cell Cycle Proteins, DNA, DNA Damage, DNA Repair, DNA-Binding Proteins, Dimerization, E2F Transcription Factors, E2F1 Transcription Factor, Gene Expression Regulation, Genome, Humans, Models, Biological, Phosphorylation, Transcription Factors, Transcription, Genetic