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[123I]-iodo-L-phenylalanine was successfully evaluated for gamma camera imaging in vivo in tumor-bearing athymic mice and in humans with brain tumors. Here, we report the use of this tracer in two dogs with synovial cell sarcoma of the tarsus. [123I]-iodo-L-phenylalanine was quantitatively prepared as a kit formulation using the Cu(1+) +-assisted nucleophilic exchange. Rapid [123I]-2-iodo-L-phenylalanine tumor accumulation was observed with good tumor to background contrast and rapid clearance in these two dogs. This radiopharmaceutical is a promising alternative tumor tracer to overcome the known limitations of 18F-fluorodeoxyglucose and, when labelled with radioiodine-131, has the potential to be used for therapeutic purposes.

Type

Journal article

Journal

Vet Radiol Ultrasound

Publication Date

09/2007

Volume

48

Pages

471 - 474

Keywords

Animals, Diagnosis, Differential, Dog Diseases, Dogs, Female, Fibula, Iodine Radioisotopes, Male, Radiography, Radiopharmaceuticals, Sarcoma, Synovial, Tibia, Tomography, Emission-Computed, Single-Photon