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Deregulation of beta-catenin activity is an important step in the development of colorectal cancers. One consequence of this is transcriptional activation of cyclin D1, an oncogene known to be overexpressed in colorectal cancers. We tested the hypothesis that cyclin D1 gene activation is important for intestinal tumorigenesis. Multiple intestinal neoplasia mice (a model for human familial adenomatous polyposis) were crossed with cyclin D1 knockout (Ccnd1(-/-)) mice. Despite the absence of cyclin D1, intestinal tumors still developed. However, Ccnd1(-/-) multiple intestinal neoplasia mice developed significantly fewer tumors than Ccnd1(+/-) or Ccnd1(+/+) mice (P = 0.003). We conclude that cyclin D1 is not essential for intestinal tumorigenesis, but it may act as a modifier gene.

Type

Journal article

Journal

Cancer Res

Publication Date

15/08/2002

Volume

62

Pages

4562 - 4565

Keywords

Animals, Cyclin D1, Cytoskeletal Proteins, Disease Models, Animal, Female, Gene Expression Regulation, Intestinal Neoplasms, Male, Mice, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Trans-Activators, Transcriptional Activation, beta Catenin