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Molecular imaging of tumour tissue focusses mainly on extracellular epitopes such as tumour angiogenesis or signal transduction receptors expressed on the cell membrane. However, most biological processes that define tumour phenotype occur within the cell. In this mini-review, an overview is given of the various techniques to interrogate intracellular events using molecular imaging with radiolabelled compounds. Additionally, similar targeting techniques can be employed for radionuclide therapy using Auger electron emitters, and recent advances in Auger electron therapy are discussed. © 2014 John Wiley & Sons, Ltd.

Original publication

DOI

10.1002/jlcr.3152

Type

Journal article

Journal

Journal of Labelled Compounds and Radiopharmaceuticals

Publication Date

01/01/2014

Volume

57

Pages

310 - 316