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Using two monoclonal antibodies directed against placental alkaline phosphatase (H17E2 and D20L) the immunohistological staining of testicular germ cell tumours was compared with that of a wide range of normal and malignant tissues. All seminomas and malignant teratomas tested gave strong positive labelling with H17E2 but were either negative or only patchily positive with D20L. Neither antibody gave any positive reaction on the normal tissues tested. All other malignancies were negative with both antibodies apart from two cases of ovarian and one case of endometrical cancer (strongly stained by H17E2) and three cases of colonic carcinoma (weakly and patchily stained by both H17E2 and D20L). This indicates that germ cell neoplasms generally express a form of placental alkaline phosphatase recognised by antibody H17E2.

Type

Journal article

Journal

Br J Cancer

Publication Date

01/1984

Volume

49

Pages

11 - 15

Keywords

Alkaline Phosphatase, Antibodies, Monoclonal, Dysgerminoma, Female, GPI-Linked Proteins, Humans, Immunoenzyme Techniques, Isoenzymes, Male, Placenta, Pregnancy, Teratoma, Testicular Neoplasms