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Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.

Original publication

DOI

10.1080/2162402X.2015.1027473

Type

Journal article

Journal

Oncoimmunology

Publication Date

09/2015

Volume

4

Keywords

CXCL10, IP-10, pancreatic cancer, pancreatic stellate cells, regulatory T cells