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The most widely cited procedures for radiolabeling antibodies with zirconium-89 for immuno-PET require multi-milligram amounts of antibody which can be cost-prohibitive, particularly during the research and development process. We therefore sought to develop a reliable (89)Zr-radiolabeling procedure that provides high radiochemical yields at the microgram scale.

Original publication

DOI

10.1039/c5dt04774a

Type

Journal article

Journal

Dalton Trans

Publication Date

21/04/2016

Volume

45

Pages

6343 - 6347

Keywords

Antibodies, Immunoconjugates, Isotope Labeling, Radioisotopes, Zirconium