Association analysis identifies 65 new breast cancer risk loci.
Michailidou K., Lindström S., Dennis J., Beesley J., Hui S., Kar S., Lemaçon A., Soucy P., Glubb D., Rostamianfar A., Bolla MK., Wang Q., Tyrer J., Dicks E., Lee A., Wang Z., Allen J., Keeman R., Eilber U., French JD., Qing Chen X., Fachal L., McCue K., McCart Reed AE., Ghoussaini M., Carroll JS., Jiang X., Finucane H., Adams M., Adank MA., Ahsan H., Aittomäki K., Anton-Culver H., Antonenkova NN., Arndt V., Aronson KJ., Arun B., Auer PL., Bacot F., Barrdahl M., Baynes C., Beckmann MW., Behrens S., Benitez J., Bermisheva M., Bernstein L., Blomqvist C., Bogdanova NV., Bojesen SE., Bonanni B., Børresen-Dale A-L., Brand JS., Brauch H., Brennan P., Brenner H., Brinton L., Broberg P., Brock IW., Broeks A., Brooks-Wilson A., Brucker SY., Brüning T., Burwinkel B., Butterbach K., Cai Q., Cai H., Caldés T., Canzian F., Carracedo A., Carter BD., Castelao JE., Chan TL., David Cheng T-Y., Seng Chia K., Choi J-Y., Christiansen H., Clarke CL., NBCS Collaborators None., Collée M., Conroy DM., Cordina-Duverger E., Cornelissen S., Cox DG., Cox A., Cross SS., Cunningham JM., Czene K., Daly MB., Devilee P., Doheny KF., Dörk T., Dos-Santos-Silva I., Dumont M., Durcan L., Dwek M., Eccles DM., Ekici AB., Eliassen AH., Ellberg C., Elvira M., Engel C., Eriksson M., Fasching PA., Figueroa J., Flesch-Janys D., Fletcher O., Flyger H., Fritschi L., Gaborieau V., Gabrielson M., Gago-Dominguez M., Gao Y-T., Gapstur SM., García-Sáenz JA., Gaudet MM., Georgoulias V., Giles GG., Glendon G., Goldberg MS., Goldgar DE., González-Neira A., Grenaker Alnæs GI., Grip M., Gronwald J., Grundy A., Guénel P., Haeberle L., Hahnen E., Haiman CA., Håkansson N., Hamann U., Hamel N., Hankinson S., Harrington P., Hart SN., Hartikainen JM., Hartman M., Hein A., Heyworth J., Hicks B., Hillemanns P., Ho DN., Hollestelle A., Hooning MJ., Hoover RN., Hopper JL., Hou M-F., Hsiung C-N., Huang G., Humphreys K., Ishiguro J., Ito H., Iwasaki M., Iwata H., Jakubowska A., Janni W., John EM., Johnson N., Jones K., Jones M., Jukkola-Vuorinen A., Kaaks R., Kabisch M., Kaczmarek K., Kang D., Kasuga Y., Kerin MJ., Khan S., Khusnutdinova E., Kiiski JI., Kim S-W., Knight JA., Kosma V-M., Kristensen VN., Krüger U., Kwong A., Lambrechts D., Le Marchand L., Lee E., Lee MH., Lee JW., Neng Lee C., Lejbkowicz F., Li J., Lilyquist J., Lindblom A., Lissowska J., Lo W-Y., Loibl S., Long J., Lophatananon A., Lubinski J., Luccarini C., Lux MP., Ma ESK., MacInnis RJ., Maishman T., Makalic E., Malone KE., Kostovska IM., Mannermaa A., Manoukian S., Manson JE., Margolin S., Mariapun S., Martinez ME., Matsuo K., Mavroudis D., McKay J., McLean C., Meijers-Heijboer H., Meindl A., Menéndez P., Menon U., Meyer J., Miao H., Miller N., Taib NAM., Muir K., Mulligan AM., Mulot C., Neuhausen SL., Nevanlinna H., Neven P., Nielsen SF., Noh D-Y., Nordestgaard BG., Norman A., Olopade OI., Olson JE., Olsson H., Olswold C., Orr N., Pankratz VS., Park SK., Park-Simon T-W., Lloyd R., Perez JIA., Peterlongo P., Peto J., Phillips K-A., Pinchev M., Plaseska-Karanfilska D., Prentice R., Presneau N., Prokofyeva D., Pugh E., Pylkäs K., Rack B., Radice P., Rahman N., Rennert G., Rennert HS., Rhenius V., Romero A., Romm J., Ruddy KJ., Rüdiger T., Rudolph A., Ruebner M., Rutgers EJT., Saloustros E., Sandler DP., Sangrajrang S., Sawyer EJ., Schmidt DF., Schmutzler RK., Schneeweiss A., Schoemaker MJ., Schumacher F., Schürmann P., Scott RJ., Scott C., Seal S., Seynaeve C., Shah M., Sharma P., Shen C-Y., Sheng G., Sherman ME., Shrubsole MJ., Shu X-O., Smeets A., Sohn C., Southey MC., Spinelli JJ., Stegmaier C., Stewart-Brown S., Stone J., Stram DO., Surowy H., Swerdlow A., Tamimi R., Taylor JA., Tengström M., Teo SH., Beth Terry M., Tessier DC., Thanasitthichai S., Thöne K., Tollenaar RAEM., Tomlinson I., Tong L., Torres D., Truong T., Tseng C-C., Tsugane S., Ulmer H-U., Ursin G., Untch M., Vachon C., van Asperen CJ., Van Den Berg D., van den Ouweland AMW., van der Kolk L., van der Luijt RB., Vincent D., Vollenweider J., Waisfisz Q., Wang-Gohrke S., Weinberg CR., Wendt C., Whittemore AS., Wildiers H., Willett W., Winqvist R., Wolk A., Wu AH., Xia L., Yamaji T., Yang XR., Har Yip C., Yoo K-Y., Yu J-C., Zheng W., Zheng Y., Zhu B., Ziogas A., Ziv E., ABCTB Investigators None., ConFab/AOCS Investigators None., Lakhani SR., Antoniou AC., Droit A., Andrulis IL., Amos CI., Couch FJ., Pharoah PDP., Chang-Claude J., Hall P., Hunter DJ., Milne RL., García-Closas M., Schmidt MK., Chanock SJ., Dunning AM., Edwards SL., Bader GD., Chenevix-Trench G., Simard J., Kraft P., Easton DF.
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P