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The immunohistochemical detection of CD1c antigen is described in mantle zone B-cells of the tonsil, lymph node, and spleen, and also in the marginal zone B-cells of the spleen. CD1c expression was observed in most cases of low-grade, but in only a single case of high-grade, B-cell non-Hodgkin's lymphoma. It was not detected in germinal centre cells, nor in Epstein-Barr virus-transformed or Burkitt's lymphoma B-cell lines. This distribution suggests that CD1c expression may occur preferentially in slowly proliferating B-cell populations and does not support previous suggestions that CD1c is a human equivalent of the mouse thymus leukaemia antigens.

Original publication




Journal article


J Pathol

Publication Date





169 - 177


Antigens, Differentiation, B-Lymphocyte, B-Lymphocytes, Humans, Lymph Nodes, Lymphoma, Non-Hodgkin, Monocytes, Palatine Tonsil, Spleen