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CAM 5.2 is a monoclonal antibody which identifies lower molecular weight cytokeratin proteins (50, 43 and 38 kD). It is an antibody which works reliably on formalin-fixed, paraffin-embedded tissues. In this study, using CAM 5.2 in the indirect immunoperoxidase method we have examined ectocervical epithelium ranging from normal, through metaplasia and cervical intraepithelial neoplasia to invasive squamous carcinoma. CAM 5.2 is demonstrated to be a useful indicator of changes associated with malignant transformation in the ectocervix.

Original publication

DOI

10.1002/path.1711480203

Type

Journal article

Journal

J Pathol

Publication Date

02/1986

Volume

148

Pages

135 - 140

Keywords

Antibodies, Monoclonal, Carcinoma, Squamous Cell, Cervix Uteri, Female, Humans, Immunoenzyme Techniques, Keratins, Metaplasia, Molecular Weight, Uterine Cervical Neoplasms