Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Serum aspartate transaminase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (gamma GT) activities and the serum ALP isoenzyme pattern have been measured in eleven patients undergoing treatment with CB3717. There were increases in the activity of all three enzymes. The ALP isoenzyme pattern showed an increased contribution of the intestinal isoenzyme to the serum ALP activity. This may be due to increased intestinal mucosal leakage or impaired uptake and breakdown of the intestinal isoenzyme by the liver.

Original publication




Journal article


J Surg Oncol

Publication Date





83 - 87


Adult, Aged, Alkaline Phosphatase, Aspartate Aminotransferases, Female, Folic Acid, Humans, Intestinal Mucosa, Isoenzymes, Liver Neoplasms, Male, Middle Aged, Quinazolines, Time Factors, gamma-Glutamyltransferase