Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Accept all cookies Reject all non-essential cookies Find out more

Search results

Showing results for

Prof. Sibson together with her co-applicants Prof. Anthony, Dr Campbell and Prof. Middleton have now been awarded a second MRC DPFS grant, for £3.3 million, to acquire further preclinical data to support the case for clinical translation, to develop the mutTNF production for human use and to undertake pre-clinical toxicology.

Histology and magnetic resonance images from a mouse with breast cancer brain metastases, injected intravenously 2 hours previously with a TNFR1-selective mutant TNF protein. 3 items in the picture: Cresyl violet stained brain section showing location of a micrometastasis. Adjacent brain section stained with Hanker-Yates demonstrates HRP extravasation (brown staining) and, hence, BBB breakdown selectively at the site of metastasis. Post-contrast (gadolinium-DTPA) image from the same mouse showing extravasation of contrast at the metastatic site (hyperintensity) confirming local BBB breakdown. Note, the BBB remains intact in the rest of the brain.
Figure caption: Histology and magnetic resonance images from a mouse with breast cancer brain metastases, injected intravenously 2 hours previously with a TNFR1-selective mutant TNF protein. (A) Cresyl violet stained brain section showing location of a micrometastasis (boxed region and inset). (B) Adjacent brain section stained with Hanker-Yates demonstrates HRP extravasation (brown staining) and, hence, BBB breakdown selectively at the site of metastasis. (C) Post-contrast (gadolinium-DTPA) image from the same mouse showing extravasation of contrast at the metastatic site (hyperintensity) confirming local BBB breakdown. Note, the BBB remains intact in the rest of the brain.

Welcome

The Department of Oncology's mission is to improve cancer care through research and teaching. There is strong emphasis on translation, with established infrastructure to develop scientific insights toward clinical appreciation.

Room Bookings

INTERCEPT-Lynch

INTERCEPT-Lynch: A Phase 1/2 Open-label, Dose-escalation, and Dose-expansion Study of mRNA-4194 in Participants with Lynch Syndrome

Site

Oxford Summer Camp 2026

Project Supervisors

MSc in Medical Physics with Radiobiology Photo Gallery

Mutational Processes in Genomic and Exonic DNA in Colorectal Cancer

Targeting transcription elongation to modulate the tumour immune microenvironment in prostate cancer

Unravel the role of the extracellular N-nicotinamide methyl transferase (eNNMT) in the modulation of radioresistant prostate cancer (PC) tumour immune microenvironment (TIME)

Graduate Information

VISTA

VISTA: Vaccination with ITOP1 in resectable oesophageal adenocarcinoma – Safety, Tolerability and Anti-Tumour activity

TrustedMDT

Student Experience

Student Experience

Use of AI in Education

Contact Us

EMERALD Pancreas: Evaluation of hypofractionated adaptive radiotherapy using the MR Linac in localised pancreatic cancer

Student Interviews

Course Overview

The MSc in Radiobiology is scheduled to run over one academic year as a full-time course consisting of eight compulsory taught modules and a research-based dissertation.

Load More