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Prof. Sibson together with her co-applicants Prof. Anthony, Dr Campbell and Prof. Middleton have now been awarded a second MRC DPFS grant, for £3.3 million, to acquire further preclinical data to support the case for clinical translation, to develop the mutTNF production for human use and to undertake pre-clinical toxicology.

Histology and magnetic resonance images from a mouse with breast cancer brain metastases, injected intravenously 2 hours previously with a TNFR1-selective mutant TNF protein. 3 items in the picture: Cresyl violet stained brain section showing location of a micrometastasis. Adjacent brain section stained with Hanker-Yates demonstrates HRP extravasation (brown staining) and, hence, BBB breakdown selectively at the site of metastasis. Post-contrast (gadolinium-DTPA) image from the same mouse showing extravasation of contrast at the metastatic site (hyperintensity) confirming local BBB breakdown. Note, the BBB remains intact in the rest of the brain.
Figure caption: Histology and magnetic resonance images from a mouse with breast cancer brain metastases, injected intravenously 2 hours previously with a TNFR1-selective mutant TNF protein. (A) Cresyl violet stained brain section showing location of a micrometastasis (boxed region and inset). (B) Adjacent brain section stained with Hanker-Yates demonstrates HRP extravasation (brown staining) and, hence, BBB breakdown selectively at the site of metastasis. (C) Post-contrast (gadolinium-DTPA) image from the same mouse showing extravasation of contrast at the metastatic site (hyperintensity) confirming local BBB breakdown. Note, the BBB remains intact in the rest of the brain.

MRC-iCASE project: From Instability to Opportunity: Therapeutic Targeting of CIN in Cancer

MRC-iCASE project: Development of next-generation anti-cancer radiopharmaceuticals

Welcome

The Department of Oncology's mission is to improve cancer care through research and teaching. There is strong emphasis on translation, with established infrastructure to develop scientific insights toward clinical appreciation.

Project Supervisors

MSc in Medical Physics with Radiobiology Photo Gallery

Mutational Processes in Genomic and Exonic DNA in Colorectal Cancer

Investigating the oncogenic role of LINC00673 in colorectal cancer

The paradox of AMER1 driver mutations in colorectal cancer

Targeting transcription elongation to modulate the tumour immune microenvironment in prostate cancer

Defining the Dendritic Cell Landscape in Human Pancreatic Cancer and Draining Lymph Nodes

Unravel the role of the extracellular N-nicotinamide methyl transferase (eNNMT) in the modulation of radioresistant prostate cancer (PC) tumour immune microenvironment (TIME)

Graduate Information

VISTA

VISTA: Vaccination with ITOP1 in resectable oesophageal adenocarcinoma – Safety, Tolerability and Anti-Tumour activity

TrustedMDT

Student Experience

Student Experience

Leveraging Macrophage Metabolism in Pancreatic Cancer

Functional genetic dissection of treatment-resistance in glioblastoma using live-cell imaging

Understanding how to effectively reprogram the immunosuppressive tumour microenvironment to improve tumour responses while limiting toxicity

Reversing T cell exhaustion through TXA2 pathway inhibition in cancer

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