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Prof. Sibson together with her co-applicants Prof. Anthony, Dr Campbell and Prof. Middleton have now been awarded a second MRC DPFS grant, for £3.3 million, to acquire further preclinical data to support the case for clinical translation, to develop the mutTNF production for human use and to undertake pre-clinical toxicology.

Histology and magnetic resonance images from a mouse with breast cancer brain metastases, injected intravenously 2 hours previously with a TNFR1-selective mutant TNF protein. 3 items in the picture: Cresyl violet stained brain section showing location of a micrometastasis. Adjacent brain section stained with Hanker-Yates demonstrates HRP extravasation (brown staining) and, hence, BBB breakdown selectively at the site of metastasis. Post-contrast (gadolinium-DTPA) image from the same mouse showing extravasation of contrast at the metastatic site (hyperintensity) confirming local BBB breakdown. Note, the BBB remains intact in the rest of the brain.
Figure caption: Histology and magnetic resonance images from a mouse with breast cancer brain metastases, injected intravenously 2 hours previously with a TNFR1-selective mutant TNF protein. (A) Cresyl violet stained brain section showing location of a micrometastasis (boxed region and inset). (B) Adjacent brain section stained with Hanker-Yates demonstrates HRP extravasation (brown staining) and, hence, BBB breakdown selectively at the site of metastasis. (C) Post-contrast (gadolinium-DTPA) image from the same mouse showing extravasation of contrast at the metastatic site (hyperintensity) confirming local BBB breakdown. Note, the BBB remains intact in the rest of the brain.

EMERALD Pancreas: Evaluation of hypofractionated adaptive radiotherapy using the MR Linac in localised pancreatic cancer

Designing Novel Vectors for Targeted In Vivo Transduction of Monocytes to Deliver Cancer Therapeutics into the Tumour Microenvironment

Student Interviews

The paradox of AMER1 driver mutations in colorectal cancer

Developing a neoantigen-like, ROP-based vaccine targeting SVN (ROP-SVN) to boost host immune responses

Tumour avatars of patients for assessment of therapeutic efficacy

Hippo signalling in Natural Killer Cells maturation and function

Hippo signalling in Natural Killer Cells maturation and function

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Welcome

The Department of Oncology's mission is to improve cancer care through research and teaching. There is strong emphasis on translation, with established infrastructure to develop scientific insights toward clinical appreciation.

Identifying unique vulnerabilities of polyploid tumour cells to enhance radiation sensitivity

Course Overview

The MSc in Radiobiology is scheduled to run over one academic year as a full-time course consisting of eight compulsory taught modules and a research-based dissertation.

UKHSA project - Identifying biomarkers to prevent medical radiation toxicity: Role of Adipose tissue in skin toxicity during radiotherapy

Characterisation of the cross-talk between the hypoxia-induced DNA damage and unfolded protein responses

Developing a novel type of cancer vaccine for genetically-defined tumours

ARCADIAN: Atovaquone with Radical ChemorADIotherapy in locally Advanced NSCLC

Accelerator technology advancements enabling MV photon FLASH radiotherapy

Developing novel therapeutic strategies to improve radiotherapy

Elucidating the role of tumour microenvironment in breast cancer metastasis

The Fanconi anaemia pathway and cancer: a molecular dissection

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