Title

Walter Bodmer

Cancer and Immunogenetics Laboratory

Our major interests are in the fundamental genetics and biology of colorectal cancer and their potential applications; and the characterisation and population distribution of genetic diversity in human populations, especially of the British Isles.

Email: 
walter.bodmer@hertford.ox.ac.uk
Telephone: 
+ 44 (0) 1865 222356
PA: 
Penny Berry
Email PA: 
penny.berry@oncology.ox.ac.uk
College: 
Hertford College

Research Summary

The fundamental genetics and biology of colorectal cancer (CRC) and their potential applications

We use a panel of over 100 colorectal cancer (CRC) cell lines to study the basic biology of colorectal cancer as well as the effects that new treatments have on the cancer cells. The cell lines have been extensively characterised for genetic mutations, expression profiles and growth characteristics.  The use of this number of cell lines allows the identification of subsets of cancers that behave similarly with respect to their biology, drug responses and growth characteristics.  This, in turn, allows us to identify the molecularly defined profiles that correlate with, and can ultimately be used to predict for, those responses. Cancer stem cells can be isolated from within individual cell lines and we are also trying to identify the genes that control stemness and cellular differentiation in CRCs.

Recently, we have developed a protocol that allows efficient establishment of medium to long-term primary cultures from fresh CRC tumour material. These are now being compared with the cell lines, both with respect to their biological properties and their drug responses.

Cancer cells grown in 3D can sometimes still form highly organised structures. The central yellow ring of staining identifies the inner luminal surface of this polarised colony of colorectal cancer cells.

The characterisation and population distribution of genetic diversity in human populations, especially of the British Isles

We have collected DNA samples from people in rural areas of the UK whose grandparents all come from within a small geographic radius. This is to reduce the effects of interbreeding between diverse populations, which has the effect of removing ancient regional differences. This serves as a very effective set of healthy controls for genetic studies into the causes of common diseases such as diabetes, psoriasis and schizophrenia. We have analysed Single Nucleotide Polymorphism data from our samples and shown a strong connection between geography and genetic variation. The genetics of normal differences, particularly facial features, are also being investigated; to this end, we are assembling a database of 3D photographs from volunteers whose genotype data we also have.

A genetic map of the UK. Each symbol is the place where a sample comes from. Individuals who belong to a genetically similar group are distinguished by colour.

 

 

Biography

In 1996, Sir Walter Bodmer assumed his current position at the Weatherall Institute of Molecular Medicine as Head of the Cancer and Immunogenetics laboratory and more recently within the Department of Oncology.  After obtaining a PhD in Genetics from Cambridge University, he moved to Stanford University in California where he rose to the position of Professor. In 1970, he returned to the UK as the first Professor of Genetics at Oxford University. He subsequently became the Director of Research, and finally the Director General, of the Imperial Cancer Research Fund in London. He is a Fellow of the Royal Society and was knighted in 1986.

Publications

SELECTED PUBLICATIONS:

Leslie S, Winney B, Hellenthal G, Davison D, Boumertit A, Day D, Hutnik K, Royrvik EC, Cunliffe B , Wellcome Trust Case Control Consortium {,International Multiple Sclerosis Genetics Consortium} Lawson DJ, Falush D, Freeman C, Pirinen M, Myers S, Robinson M, Donnelly P and Bodmer WF (2015) The fine-scale genetic structure of the British population. Nature 519: 309-314.

Ashley N, Jones M, Ouaret D, Wilding J and Bodmer WF (2014) Rapidly derived colorectal cancer cultures recapitulate parental cancer characteristics and enable personalized therapeutic assays. J Pathol 2014; 234: 34–45

Ashley N, Yeung TM, Bodmer WF. Stem cell differentiation and lumen formation in colorectal cancer cell lines and primary tumors. Cancer research. 2013;73:5798-809.

Winney B, Boumertit A, Day T, Davison D, Echeta C, Evseeva I, et al. People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population. European journal of human genetics : EJHG. 2012;20:203-10.Ashraf SQ,

Ashraf, SQ, Nicholls AM, Wilding JL, Ntouroupi TG, Mortensen NJ, Bodmer WF. Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel. Proc Natl Acad Sci U S A. 2012.

Associated Researchers

Group Members

Mustak Ayub, DPhil Student  
Tom Barnes, Clinical Research Fellow                                                                                                                                                                                                                                                                                     
Laura Colling, DPhil Student
Daniel Crouch, Postdoctoral Researcher
Tammy Day, Research Nurse
Kasia Hutnik, Postdoctoral Researcher                                                                                                                                                                                                                                                                        
Peter Kalugin, MRes Student
Haoyu Liu, DPhil Student
Devendra Meena, DPhil Student
Marahaini Musa, DPhil Student
Djamila Ouaret, Postdoctoral Researcher
Jenny Wilding, Postdoctoral Researcher 
                                                                                                                                                                                                                                                                                                                                             

 

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