Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Associate Professor Peter McHugh of the Department of Oncology has been awarded a 4 year grant from the Medical Research Council.

The news comes hot on the heels of Professor McHugh's Cancer Research UK programme award. Grant success is tough, so this is a truly impressive achievement.

The MRC funded work focusses on the repair of DNA interstrand crosslinks (ICLs), which are formed when the two strands of the DNA double-helix become covalently linked together. ICLs are an extremely toxic form of DNA damage that prevent cellular fundamental processes including DNA replication and transcription. Defects in ICL repair result in cancer pre-disposition syndromes, such as Fanconi anemia, underlining the importance of ICL repair in human development and cancer avoidance.

Conversely, many important cancer chemotherapeutics work through ICL formation. Together, these facts emphasise the importance of understanding ICL repair for improving cancer prevention and treatment strategies.

Professor McHugh said of the project: "Here, the team aim to understand the nucleases and associated proteins that act to incise the DNA during ICL repair, with a focus on the XPF(FANCQ)-ERCC1 endonuclease, and the associated SLX4(FANCP) factor. We are using a combination of biochemical and structural approaches to reveal how these nuclease complexes are delivered to sites of DNA damage during DNA replication, and to characterise the reactions they undertake to initiate DNA repair at the replication fork."

Congratulations Professor McHugh and good luck with the research.

Similar stories

Further funding secured to hunt out cancer using innovative radiotherapy techniques

Initial success leads to new award for Oxford researcher pushing forward new cancer-hunting radiotherapy despite lockdown.

Oxford University to lead a new national programme of AI research to improve lung cancer screening

UK Research and Innovation, Cancer Research UK and industry are investing more than £11 million in an Oxford-led artificial intelligence (AI) research programme to improve the diagnosis of lung cancer and other thoracic diseases.

Breast Cancer Grant for Prof Ramadan

Congratulations to Prof Kristijan Ramadan who has been awarded a three year research grant from Breast Cancer Now. The grant will support Dr. Abhay Narayan Singh who will explore new ways to use chemotherapy in order to improve the outcomes for women with breast cancer.

Professor Anna Schuh awarded funding from the NIHR RIGHT programme

The NIHR has invested £34 million of funding into global health research projects to tackle epilepsy, infection-related cancers and severe stigmatising skin diseases in low- and middle-income countries (LMICs).

A tempting new target for cancer therapy

Kristijan Ramadan and his group published a new article in The EMBO Journal today. The article adds new detail to the story of how our cells repair damage to our DNA.

New 'molecular fibres' may help cells repair DNA

Research by the DNA Damage & Disease research group has for the first time observed molecular fibres that may hold together sections of broken DNA in mitosis.