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In response to DNA damage, E2F-1 is induced and phosphorylated. Phosphorylated E2F-1 can reside in discrete nuclear structures and induce apoptosis, suggesting a unique role for E2F-1 in DNA repair and checkpoint functions.

Type

Journal article

Journal

Cell Cycle

Publication Date

09/2003

Volume

2

Pages

435 - 437

Keywords

Animals, Apoptosis, Cell Cycle, Cell Cycle Proteins, Cell Nucleus, DNA Damage, DNA Repair, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, Humans, Mitogen-Activated Protein Kinases, Phosphorylation, Signal Transduction, Transcription Factors, Tumor Suppressor Protein p53