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How tumor cells adapt and survive under hypoxia significantly impacts patient prognosis. We recently demonstrated that the oxygen-requiring ribonucleotide reductase (RNR) enzyme, which provides cells with deoxyribonucleotides, responds to limited oxygen availability by switching small subunits from RRM2 to RRM2B. This property of RNR is essential for hypoxic cell viability and therefore contributes to the most aggressive and therapy-resistant fraction of tumors.

Original publication

DOI

10.1080/23723556.2017.1335272

Type

Journal article

Journal

Mol Cell Oncol

Publication Date

2017

Volume

4

Keywords

Hypoxia, Replication stress, Ribonucleotide reductase