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We have undertaken a retrospective analysis of 238 patients with Stages I and II seminoma of the testis treated with radiotherapy in Edinburgh between 1974 and 1989. There were five deaths from seminoma. Cause-specific survival for the whole group at 2 and 5 years was 99.2% and 98.1%, respectively. Cause-specific survival at 2 and 5 years by stage (Royal Marsden staging classification) was: Stage I, 99.5% and 98.7% and Stage II, 98.1% and 96.1%. Fourteen (5.9%) patients relapsed (one after treatment for his second testicular seminoma). Eight were given successful salvage treatment, five died of seminoma and one died of intercurrent disease. 13 (5.5%) patients developed World Health Organisation (WHO) grade 3 gastrointestinal or haematological toxicity and two developed grade 4 gastrointestinal toxicity as a result of abdominal radiotherapy. 22 patients (9.2%) developed problems ascribed to late morbidity of abdominal radiotherapy including 18 with peptic ulcer disease. Contralateral testicular tumours occurred in seven (2.9%) patients and five (2.1%) patients developed malignancies at other sites.

Original publication

DOI

10.1259/0007-1285-68-808-400

Type

Journal article

Journal

Br J Radiol

Publication Date

04/1995

Volume

68

Pages

400 - 405

Keywords

Adolescent, Adult, Aged, Humans, Male, Middle Aged, Morbidity, Neoplasm Recurrence, Local, Neoplasm Staging, Neoplasms, Radiation-Induced, Neoplasms, Second Primary, Orchiectomy, Radiotherapy, Adjuvant, Retrospective Studies, Seminoma, Survival Rate, Testicular Neoplasms