Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

© Springer International Publishing Switzerland 2016. Radiation is a very effective form of cancer therapy but its effectiveness is significantly influenced by changes in the levels of oxygen, nutrients and pH in the tumor microenvironment. Radiation dose is also limited by normal tissue toxicity, which can manifest itself both in early effects as well as in late effects. Therefore, approaches aimed at improving the therapeutic window for radiotherapy should consider both the effects of the tumor microenvironment such as hypoxia, and also target pathways that may reduce radiation-induced normal tissue toxicity. With these concepts in mind, we review the biological consequences of tumor hypoxia and the effects of hypoxia/HIF on tumor radiation sensitivity as well as the effects of targeting the HIF/PHD axis for normal tissue radioprotection.

Original publication

DOI

10.1007/978-3-319-45594-5_2

Type

Chapter

Book title

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment

Publication Date

01/01/2016

Pages

29 - 42