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Publications

How Cells Respond to DNA Breaks in Mitosis.

Blackford AN. and Stucki M., (2020), Trends Biochem Sci

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.

Leimbacher P-A. et al, (2019), Mol Cell, 74, 571 - 583.e8

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity.

Becker JR. et al, (2018), Nat Commun, 9

Structural Insight into BLM Recognition by TopBP1.

Sun L. et al, (2017), Structure, 25, 1582 - 1588.e3

PGBD5 promotes site-specific oncogenic mutations in human tumors.

Henssen AG. et al, (2017), Nat Genet, 49, 1005 - 1014

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.

Blackford AN. and Jackson SP., (2017), Mol Cell, 66, 801 - 817

Synthetic lethality between PAXX and XLF in mammalian development.

Balmus G. et al, (2016), Genes Dev, 30, 2152 - 2157

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.

Lescale C. et al, (2016), Cell Rep, 16, 2967 - 2979

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.

Harley ME. et al, (2016), Nat Genet, 48, 36 - 43

USP4 Auto-Deubiquitylation Promotes Homologous Recombination.

Wijnhoven P. et al, (2015), Mol Cell, 60, 362 - 373

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.

Higgs MR. et al, (2015), Mol Cell, 59, 462 - 477

TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.

Blackford AN. et al, (2015), Mol Cell, 57, 1133 - 1141

TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.

Broderick R. et al, (2015), Nat Commun, 6

DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.

Ochi T. et al, (2015), Science, 347, 185 - 188

DNA Ligases

Blackford AN., (2013), Brenner's Encyclopedia of Genetics: Second Edition, 371 - 372

The DNA translocase activity of FANCM protects stalled replication forks.

Blackford AN. et al, (2012), Hum Mol Genet, 21, 2005 - 2016

Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.

Polo SE. et al, (2012), Mol Cell, 45, 505 - 516

Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection.

Forrester NA. et al, (2011), J Virol, 85, 2201 - 2211

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation.

Blackford AN. et al, (2010), Proc Natl Acad Sci U S A, 107, 12251 - 12256

A novel ATRibute of FANCM.

Blackford AN. et al, (2010), Cell Cycle, 9, 1453 - 1455

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