Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Continue

Publications

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.

Shorrocks A-MK. et al, (2021), Nat Commun, 12

CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.

Ochi T. et al, (2020), Structure

How Cells Respond to DNA Breaks in Mitosis.

Blackford AN. and Stucki M., (2020), Trends Biochem Sci

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation.

Mooser C. et al, (2020), Nat Commun, 11

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.

Leimbacher P-A. et al, (2019), Mol Cell, 74, 571 - 583.e8

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity.

Becker JR. et al, (2018), Nat Commun, 9

Structural Insight into BLM Recognition by TopBP1.

Sun L. et al, (2017), Structure, 25, 1582 - 1588.e3

PGBD5 promotes site-specific oncogenic mutations in human tumors.

Henssen AG. et al, (2017), Nat Genet, 49, 1005 - 1014

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.

Blackford AN. and Jackson SP., (2017), Mol Cell, 66, 801 - 817

Synthetic lethality between PAXX and XLF in mammalian development.

Balmus G. et al, (2016), Genes Dev, 30, 2152 - 2157

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.

Lescale C. et al, (2016), Cell Rep, 16, 2967 - 2979

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.

Harley ME. et al, (2016), Nat Genet, 48, 36 - 43

USP4 Auto-Deubiquitylation Promotes Homologous Recombination.

Wijnhoven P. et al, (2015), Mol Cell, 60, 362 - 373

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.

Higgs MR. et al, (2015), Mol Cell, 59, 462 - 477

TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.

Blackford AN. et al, (2015), Mol Cell, 57, 1133 - 1141

TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.

Broderick R. et al, (2015), Nat Commun, 6

DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.

Ochi T. et al, (2015), Science, 347, 185 - 188

DNA Ligases

Blackford AN., (2013), Brenner's Encyclopedia of Genetics: Second Edition, 371 - 372

The DNA translocase activity of FANCM protects stalled replication forks.

Blackford AN. et al, (2012), Hum Mol Genet, 21, 2005 - 2016

Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.

Polo SE. et al, (2012), Mol Cell, 45, 505 - 516

Load More