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Publications

Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms.

Sivakumar S. et al, (2025), Nat Commun, 16

Defining the genetic determinants of CD8+T cell receptor repertoire in the context of immune checkpoint blockade

Ng ES. et al, (2024)

Cytomegalovirus infection protects against metastatic melanoma and modulates oncological outcome and toxicity to checkpoint immunotherapy

Milotay G. et al, (2024)

SCALABLE MULTIPLE NETWORK INFERENCE WITH THE JOINT GRAPHICAL HORSESHOE

Lingjærde C. et al, (2024), Annals of Applied Statistics, 18, 1899 - 1923

Genetic determinants of monocyte splicing are enriched for disease susceptibility loci including for COVID-19

Fairfax B. et al, (2024)

An isoform quantitative trait locus in SBNO2 links genetic susceptibility to Crohn's disease with defective antimicrobial activity.

Aschenbrenner D. et al, (2024), Nat Commun, 15

Severe acute myositis and myocarditis on initiation of 6-weekly pembrolizumab post-COVID-19 mRNA vaccination.

Watson RA. et al, (2024), J Immunother Cancer, 12

Characterization of the genetic determinants of context-specific DNA methylation in primary monocytes.

Gilchrist JJ. et al, (2024), Cell Genom

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy.

Chong AY. et al, (2024), Am J Hum Genet, 111, 295 - 308

Demultiplexing of single-cell RNA-sequencing data using interindividual variation in gene expression.

Nassiri I. et al, (2024), Bioinform Adv, 4

Peripheral monocyte transcriptomics associated with immune checkpoint blockade outcomes in metastatic melanoma

Cooper R. et al, (2024)

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

Sivakumar S. et al, (2023)

A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation.

Javaid H. et al, (2023), BMC Cancer, 23

scQCEA: a framework for annotation and quality control report of single-cell RNA-sequencing data.

Nassiri I. et al, (2023), BMC Genomics, 24

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.

Pairo-Castineira E. et al, (2023), Nature, 619

Characterisation of the genetic determinants of context specific DNA methylation in primary monocytes

Gilchrist JJ. et al, (2023)

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.

Pairo-Castineira E. et al, (2023), Nature, 617, 764 - 768

Deep sequencing of the T cell Receptor reveals common and reproducible CD8+signatures of response to checkpoint immunotherapy

Watson RA. et al, (2023)

IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells.

Mazet JM. et al, (2023), Nat Commun, 14

Germline variants associated with toxicity to immune checkpoint blockade.

Groha S. et al, (2022), Nat Med

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