High throughput mutational characterization of the GPCR ligand C5a using yeast display and deep sequencing.
Xu Y. et al, (2025), Structure
Tissue-specific iron levels modulate lipid peroxidation and the FLASH radiotherapy effect.
Vilaplana-Lopera N. et al, (2025), Cell Death Dis, 16
Tissue-Specific Iron Levels Modulate Lipid Peroxidation and the FLASH Radiotherapy Effect.
Vilaplana-Lopera N. et al, (2025)
Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation.
Estephan H. et al, (2025), EMBO J, 44, 903 - 922
Hypoxia inhibits MHC I expression and antigen presentation to escape immune surveillance
ESTEPHAN H. et al, (2024), EMBO Journal
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.
Beach C. et al, (2024), J Clin Invest, 134
Tirapazamine sensitizes homologous recombination-proficient cancers by enhancing DNA damage andferroptosis
Jiang Y. et al, (2024), CANCER RESEARCH, 84
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.
Beach C. et al, (2023), J Clin Invest, 133
Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity.
Byun J-K. et al, (2023), Br J Cancer, 128, 1491 - 1502
Targeting AXL Using the AVB-500 Soluble Receptor and through Genetic Knockdown Inhibits Bile Duct Cancer Growth and Metastasis.
Kim J. et al, (2023), Cancers (Basel), 15
Ferroptosis, a key to unravel the enigma of the FLASH effect?
Vilaplana-Lopera N. et al, (2022), Br J Radiol, 95
ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma.
Klasson TD. et al, (2022), Cancer Metab, 10
The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT.
Moon EJ. et al, (2022), Int J Radiat Biol, 98, 439 - 451
A NIR fluorescent smart probe for imaging tumor hypoxia.
Hettie KS. et al, (2021), Cancer Rep (Hoboken), 4
Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer.
Miao YR. et al, (2021), Clin Cancer Res, 27, 4435 - 4448
The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling.
Moon EJ. et al, (2021), Nat Commun, 12
Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models.
Mehibel M. et al, (2021), J Clin Invest, 131

