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Publications

Galectin-3 induces neurodevelopmental apical-basal polarity and regulates gyrification.

Soares LC. et al, (2025), Sci Adv, 11

Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA.

Murphy L. et al, (2025), Science, 389

Induction of macrophage efferocytosis in pancreatic cancer via PI3Kγ inhibition and radiotherapy promotes tumour control.

Russell SN. et al, (2025), Gut, 74, 825 - 839

ATR-hippo drives force signaling to nuclear F-actin and links mechanotransduction to neurological disorders.

Chatzifrangkeskou M. et al, (2025), Sci Adv, 11

DNA-damage orchestrates self-renewal and differentiation via reciprocal p53 family and Hippo/Wnt/TGF-β pathway activation in embryonic stem cells.

Ye Y. et al, (2025), Cell Mol Life Sci, 82

Standard or high dose chemoradiotherapy, with or without the protease inhibitor nelfinavir, in patients with locally advanced pancreatic cancer: The phase 1/randomised phase 2 SCALOP-2 trial.

Mukherjee S. et al, (2024), Eur J Cancer, 209

Development of human pancreatic cancer avatars as a model for dynamic immune landscape profiling and personalized therapy.

Hughes D. et al, (2024), Sci Adv, 10

Targeting PI3K-gamma in myeloid driven tumour immune suppression: A Systematic Review and Meta-Analysis of the Preclinical Literature

Xu H. et al, (2024)

53BP1-mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling.

Tsaridou S. et al, (2022), EMBO Rep, 23

Chemical-induced gene expression ranking and its application to pancreatic cancer drug repurposing.

Pham T-H. et al, (2022), Patterns (N Y), 3

RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1.

Papaspyropoulos A. et al, (2022), EMBO Rep, 23

RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis.

Tognoli ML. et al, (2021), EMBO J, 40

TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes.

Eyres M. et al, (2021), Gastroenterology, 161, 653 - 668.e16

Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse.

Bangs FK. et al, (2020), Dis Model Mech, 13

Galectin-3 modulates postnatal subventricular zone gliogenesis.

Al-Dalahmah O. et al, (2020), Glia, 68, 435 - 450

Assessment of CCR5/maraviroc immunotherapy in combination with PD1 and MR-guided radiotherapy for treatment of pancreatic cancer.

Hughes S. et al, (2020), CANCER IMMUNOLOGY RESEARCH, 8, 120 - 120

Translational analysis from SCALOP trial: CCL5 as a prognostic biomarker and a potentially actionable target in locally advanced pancreatic cancer (LAPC)

Mukherjee S. et al, (2020), JOURNAL OF CLINICAL ONCOLOGY, 38

RAS in pancreatic cancer.

Lanfredini S. et al, (2019), Biochem Soc Trans, 47, 961 - 972

RASSF1A is required for the maintenance of nuclear actin levels.

Chatzifrangkeskou M. et al, (2019), EMBO J, 38

CCL5 is associated with poor prognosis in locally advanced pancreatic cancer (LAPC): biomarker analysis from the randomised phase II SCALOP trial.

Willenbrock F. et al, (2019), Ann Oncol, 30 Suppl 4

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