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Publications

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin.

Lord SR. et al, (2019), Br J Cancer

MITF controls the TCA cycle to modulate the melanoma hypoxia response.

Louphrasitthiphol P. et al, (2019), Pigment Cell Melanoma Res, 32, 792 - 808

E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.

Burdova K. et al, (2019), EMBO J, 38

Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism.

Valli A. et al, (2019), Mol Cancer Res, 17, 1531 - 1544

Defining the role of AP1 in molecular adaptation to hypoxia in colorectal cancer

Vancauwenberghe E. et al, (2019), CANCER RESEARCH, 79

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.

Morotti M. et al, (2019), Proc Natl Acad Sci U S A, 116, 12452 - 12461

Science in Focus: Bioinformatics Part 1 - Lost in Translation.

O'Cathail SM. and Buffa FM., (2019), Clin Oncol (R Coll Radiol), 31, 337 - 340

Guidelines for using sigQC for systematic evaluation of gene signatures.

Dhawan A. et al, (2019), Nat Protoc, 14, 1377 - 1400

Identification of anticancer drugs to radiosensitise BRAF-wild-type and mutant colorectal cancer.

Carter R. et al, (2019), Cancer Biol Med, 16, 234 - 246

Genomic Signatures From Bench to Bedside - a Protocol for Translation: sigQC

Dhawan A. et al, (2019), NEUROLOGY, 92

Modelling genotypes in their microenvironment to predict single- and multi-cellular behaviour.

Voukantsis D. et al, (2019), Gigascience

The many faces of mathematical modelling in oncology.

Victori P. and Buffa FM., (2019), Br J Radiol, 92

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors.

Dhawan A. et al, (2018), Nat Commun, 9

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer.

Lord SR. et al, (2018), Cell Metab, 28, 679 - 688.e4

Are Signatures of Radiosensitivity Ready for Routine Clinical Use? a Pragmatic Comparison of Clinical, Pathological and Gene Signature Predictors of Outcome in Oropharynx Head and Neck Cancers

Dhawan A. et al, (2018), INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 102, S137 - S138

Integrated pharmacodynamic analysis identifies two metabolic adaption pathways to metformin in breast cancer

Lord S. et al, (2018), EUROPEAN JOURNAL OF CANCER, 103, E118 - E118

Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network.

Dhawan A. et al, (2018), J Theor Biol

Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project.

Robbe P. et al, (2018), Genet Med, 20, 1196 - 1205

The evolutionary landscape of colorectal tumorigenesis.

Cross W. et al, (2018), Nat Ecol Evol, 2, 1661 - 1672

Nucleoporin 54 contributes to homologous recombination repair and post-replicative DNA integrity.

Rodriguez-Berriguete G. et al, (2018), Nucleic Acids Res, 46, 7731 - 7746

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