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Publications

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks

Song W. et al, (2024)

TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival.

Lascaux P. et al, (2024), Cell, 187, 5698 - 5718.e26

Isolation and detection of DNA-protein crosslinks in mammalian cells.

Torrecilla I. et al, (2023), Nucleic Acids Res

Atypical K6-ubiquitin chains mobilize p97/VCP and the proteasome to resolve formaldehyde-induced RNA-protein crosslinks.

Song W. and Ramadan K., (2023), Mol Cell, 83, 4197 - 4199

ATXN3 controls DNA replication and transcription by regulating chromatin structure.

Hernández-Carralero E. et al, (2023), Nucleic Acids Res

Inhibitors of the ATPase p97/VCP: From basic research to clinical applications

Kilgas S. and Ramadan K., (2023), Cell Chemical Biology, 30, 3 - 21

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

Krastev DB. et al, (2022), Nat Cell Biol

Immunofluorescence microscopy-based detection of ssDNA foci by BrdU in mammalian cells.

Kilgas S. et al, (2021), STAR Protoc, 2

The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability.

Ruggiano A. et al, (2021), Cell Rep, 37

The NUCKS1-SKP2-p21/p27 axis controls S phase entry.

Hume S. et al, (2021), Nat Commun, 12

Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review.

Bolland H. et al, (2021), Biochem Soc Trans, 49, 1251 - 1263

p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation.

Kilgas S. et al, (2021), Cell Rep, 35

Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress.

Herbert KJ. et al, (2021), Cell Death Differ, 28, 1333 - 1346

TEX264 at the intersection of autophagy and DNA repair.

Fielden J. et al, (2021), Autophagy, 1 - 10

SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells.

Na J. et al, (2021), Cell Death Dis, 12

DNA-protein crosslink proteases in genome stability.

Ruggiano A. and Ramadan K., (2021), Commun Biol, 4

The Trinity of SPRTN Protease Regulation.

Ruggiano A. and Ramadan K., (2021), Trends Biochem Sci, 46, 2 - 4

A unified model for the G1/S cell cycle transition.

Hume S. et al, (2020), Nucleic Acids Res, 48, 12483 - 12501

SPRTN protease and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

RAMADAN K., (2020), BioRXiv

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.

Fielden J. et al, (2020), Nat Commun, 11

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