DNA-protein crosslink proteases in genome stability.
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Ruggiano A. and Ramadan K., (2021), Commun Biol, 4
The Trinity of SPRTN Protease Regulation.
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Ruggiano A. and Ramadan K., (2020), Trends Biochem Sci
SPRTN protease and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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RAMADAN K., (2020), BioRXiv
TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.
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Fielden J. et al, (2020), Nat Commun, 11
The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification
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Wells C. et al, (2019), BioRxiv
The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8.
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Singh AN. et al, (2019), EMBO J, 38
SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.
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Halder S. et al, (2019), Nat Commun, 10
DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans.
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Fielden J. et al, (2018), DNA Repair (Amst), 71, 198 - 204
Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients.
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Chen X. et al, (2018), Cell Oncol (Dordr), 41, 527 - 539
The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.
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A three-in-one-bullet for oesophageal cancer: replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(ii) metallo-intercalator.
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The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks.
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DNA-Protein Crosslink Proteolysis Repair.
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Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication.
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Ramadan K. et al, (2017), Chromosoma, 126, 17 - 32
Editorial: Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response.
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Ramadan K. and Dikic I., (2017), Front Genet, 8
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.
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A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition.
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Gill MR. et al, (2016), Sci Rep, 6
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.
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Franz A. et al, (2016), Nat Commun, 7
Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.
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Zimmer J. et al, (2016), Mol Cell, 61, 449 - 460
Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.
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