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Publications

SPRTN protease and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

RAMADAN K., (2020), BioRXiv

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.

Fielden J. et al, (2020), Nat Commun, 11

The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification

Wells C. et al, (2019), BioRxiv

The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8.

Singh AN. et al, (2019), EMBO J, 38

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.

Halder S. et al, (2019), Nat Commun, 10

DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans.

Fielden J. et al, (2018), DNA Repair (Amst), 71, 198 - 204

Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients.

Chen X. et al, (2018), Cell Oncol (Dordr), 41, 527 - 539

The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.

Baranes-Bachar K. et al, (2018), Mol Cell, 69, 866 - 878.e7

A three-in-one-bullet for oesophageal cancer: replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(ii) metallo-intercalator.

Gill MR. et al, (2018), Chem Sci, 9, 841 - 849

The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks.

Torrecilla I. et al, (2017), Philos Trans R Soc Lond B Biol Sci, 372

DNA-Protein Crosslink Proteolysis Repair.

Vaz B. et al, (2017), Trends Biochem Sci, 42, 483 - 495

Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication.

Ramadan K. et al, (2017), Chromosoma, 126, 17 - 32

Editorial: Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response.

Ramadan K. and Dikic I., (2017), Front Genet, 8

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.

Vaz B. et al, (2016), Mol Cell, 64, 704 - 719

A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition.

Gill MR. et al, (2016), Sci Rep, 6

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.

Franz A. et al, (2016), Nat Commun, 7

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Zimmer J. et al, (2016), Mol Cell, 61, 449 - 460

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.

Lessel D. et al, (2014), Nat Genet, 46, 1239 - 1244

Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity.

Puumalainen M-R. et al, (2014), Nat Commun, 5

Wip1 downregulation conserves truncated DNA damage response (DDR) in mitosis.

Vaz B. and Ramadan K., (2013), Cell Cycle, 12

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