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Publications

The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity.

Liu G. et al, (2023), Commun Biol, 6

CXD101 and nivolumab in patients with metastatic microsatellite-stable colorectal cancer (CAROSELL): a multicentre, open-label, single-arm, phase II trial.

Saunders MP. et al, (2022), ESMO Open, 7

Immune modulation underpins the anti-cancer activity of HDAC inhibitors.

Blaszczak W. et al, (2021), Mol Oncol

PRMT5 promotes cancer cell migration and invasion through the E2F pathway.

Barczak W. et al, (2020), Cell Death Dis, 11

Arginine methylation expands the regulatory mechanisms and extends the genomic landscape under E2F control.

Roworth AP. et al, (2019), Sci Adv, 5

A phase 1 study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer.

Eyre TA. et al, (2019), Cancer, 125, 99 - 108

Functional interplay between E2F7 and ribosomal rRNA gene transcription regulates protein synthesis.

Coutts AS. et al, (2018), Cell Death Dis, 9

Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein.

Carr SM. et al, (2017), Cell Death Differ, 24, 2139 - 2149

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function.

Munro S. et al, (2017), Cell Rep, 19, 2193 - 2201

Transfection

Sheikh S. et al, (2017), Basic Science Methods for Clinical Researchers, 191 - 209

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.

Tumber A. et al, (2017), Cell Chem Biol, 24, 371 - 380

CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation.

Olzscha H. et al, (2017), Cell Chem Biol, 24, 9 - 23

Bromodomains control amyloid-like aggregation of aberrantly acetylated proteins.

Olzscha H. et al, (2017), MOLECULAR BIOLOGY OF THE CELL, 28

Linking H1 with chromatin and growth control.

Munro S. and La Thangue NB., (2017), Mol Cell Oncol, 4

The TLR Adaptor Protein MyD88 Mediates Cell Sensitivity to HDAC Inhibitors through a Cytokine-Dependent Mechanism

Sheikh S. et al, (2016), BLOOD, 128

TLR Adaptor Protein MYD88 Mediates Sensitivity to HDAC Inhibitors via a Cytokine-Dependent Mechanism.

New M. et al, (2016), Cancer Res, 76, 6975 - 6987

Regulation of actin nucleation and autophagosome formation.

Coutts AS. and La Thangue NB., (2016), Cell Mol Life Sci, 73, 3249 - 3263

Structural analysis of human KDM5B guides histone demethylase inhibitor development.

Johansson C. et al, (2016), Nat Chem Biol, 12, 539 - 545

Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.

Kawalkowska J. et al, (2016), Sci Rep, 6

ABROGATION OF COLLAGEN-INDUCED ARTHRITIS BY A SECOND GENERATION PEPTIDYL ARGININE DEIMINASE INHIBITOR IS ASSOCIATED WITH A SHIFT FROM TH1/TH17 TO TH2-MEDIATED IMMUNE RESPONSES

Kawalkowska J. et al, (2016), ANNALS OF THE RHEUMATIC DISEASES, 75, A56 - A56

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