The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity.
Journal article
Liu G. et al, (2023), Commun Biol, 6
CXD101 and nivolumab in patients with metastatic microsatellite-stable colorectal cancer (CAROSELL): a multicentre, open-label, single-arm, phase II trial.
Journal article
Saunders MP. et al, (2022), ESMO Open, 7
Immune modulation underpins the anti-cancer activity of HDAC inhibitors.
Journal article
Blaszczak W. et al, (2021), Mol Oncol
PRMT5 promotes cancer cell migration and invasion through the E2F pathway.
Journal article
Barczak W. et al, (2020), Cell Death Dis, 11
Arginine methylation expands the regulatory mechanisms and extends the genomic landscape under E2F control.
Journal article
Roworth AP. et al, (2019), Sci Adv, 5
A phase 1 study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer.
Journal article
Eyre TA. et al, (2019), Cancer, 125, 99 - 108
Functional interplay between E2F7 and ribosomal rRNA gene transcription regulates protein synthesis.
Journal article
Coutts AS. et al, (2018), Cell Death Dis, 9
Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein.
Journal article
Carr SM. et al, (2017), Cell Death Differ, 24, 2139 - 2149
Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function.
Journal article
Munro S. et al, (2017), Cell Rep, 19, 2193 - 2201
Transfection
Chapter
Sheikh S. et al, (2017), Basic Science Methods for Clinical Researchers, 191 - 209
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
Journal article
Tumber A. et al, (2017), Cell Chem Biol, 24, 371 - 380
CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation.
Journal article
Olzscha H. et al, (2017), Cell Chem Biol, 24, 9 - 23
Bromodomains control amyloid-like aggregation of aberrantly acetylated proteins.
Conference paper
Olzscha H. et al, (2017), MOLECULAR BIOLOGY OF THE CELL, 28
Linking H1 with chromatin and growth control.
Journal article
Munro S. and La Thangue NB., (2017), Mol Cell Oncol, 4
The TLR Adaptor Protein MyD88 Mediates Cell Sensitivity to HDAC Inhibitors through a Cytokine-Dependent Mechanism
Conference paper
Sheikh S. et al, (2016), BLOOD, 128
TLR Adaptor Protein MYD88 Mediates Sensitivity to HDAC Inhibitors via a Cytokine-Dependent Mechanism.
Journal article
New M. et al, (2016), Cancer Res, 76, 6975 - 6987
Regulation of actin nucleation and autophagosome formation.
Journal article
Coutts AS. and La Thangue NB., (2016), Cell Mol Life Sci, 73, 3249 - 3263
Structural analysis of human KDM5B guides histone demethylase inhibitor development.
Journal article
Johansson C. et al, (2016), Nat Chem Biol, 12, 539 - 545
Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.
Journal article
Kawalkowska J. et al, (2016), Sci Rep, 6
ABROGATION OF COLLAGEN-INDUCED ARTHRITIS BY A SECOND GENERATION PEPTIDYL ARGININE DEIMINASE INHIBITOR IS ASSOCIATED WITH A SHIFT FROM TH1/TH17 TO TH2-MEDIATED IMMUNE RESPONSES
Conference paper
Kawalkowska J. et al, (2016), ANNALS OF THE RHEUMATIC DISEASES, 75, A56 - A56