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Publications

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Yosaatmadja Y. et al, (2021)

Repeat expansions confer WRN dependence in microsatellite-unstable cancers.

van Wietmarschen N. et al, (2020), Nature, 586, 292 - 298

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock HT. et al, (2020)

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock H. et al, (2020)

The SNM1A DNA repair nuclease.

Baddock HT. et al, (2020), DNA Repair (Amst), 95

Genetic and functional insights into CDA-I prevalence and pathogenesis.

Olijnik A-A. et al, (2020), J Med Genet

XPF-ERCC1: Linchpin of DNA crosslink repair

MCHUGH P., (2020), PLoS Genetics

The analysis of DNA interstrand crosslinks and their repair by the modified Comet assay

SWIFT LP. et al, (2020), DNA Electrophoresis: Methods and Protocols., 2119

Optimised oligonucleotide substrates to assay XPF ERCC1 nuclease activity for the discovery of DNA repair inhibitors†

MCHUGH PJ. et al, (2019), Chemical Communications

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.

Doherty W. et al, (2019), Org Biomol Chem

Microhomologies are prevalent at Cas9-induced larger deletions

Owens DDG. et al, (2019), Nucleic Acids Research

Antiviral activity of bone morphogenetic proteins and activins.

Eddowes LA. et al, (2019), Nat Microbiol, 4, 339 - 351

Squaramide-Based 5’-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A

Dürr EM. et al, (2018), ChemistrySelect, 3, 12824 - 12829

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.

Amunugama R. et al, (2018), Cell Rep, 23, 3419 - 3428

Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.

MacGregor TP. et al, (2018), Sci Rep, 8

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.

Ronson GE. et al, (2018), Nat Commun, 9

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Cain R. et al, (2018), J Med Chem, 61, 1255 - 1260

Third EU-US workshop on "Nucleotide excision repair and crosslink repair-From molecules to mankind", Smolenice Castle, Slovak Republic, May 7th-11th 2017

McHugh PJ. et al, (2017), DNA Repair, 58

RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.

Abdullah UB. et al, (2017), EMBO J, 36, 2047 - 2060

RPA activates XPF-ERCC1 to initiate the processing of DNA

Mchugh P. et al, (2017), The EMBO Journal

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