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Publications

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock HT. et al, (2022), Nucleic Acids Research

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.

Baddock HT. et al, (2021), Nucleic acids research

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.

Yosaatmadja Y. et al, (2021), Nucleic Acids Res

Neuronal enhancers are hotspots for DNA single-strand break repair.

Wu W. et al, (2021), Nature

The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core

MCHUGH P. and PTCHELKINE D., (2021), Nucleic Acids Research Cancer

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Yosaatmadja Y. et al, (2021)

Repeat expansions confer WRN dependence in microsatellite-unstable cancers.

van Wietmarschen N. et al, (2020), Nature, 586, 292 - 298

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock H. et al, (2020)

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

BADDOCK HT. et al, (2020), bioRxiv

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock H. et al, (2020), bioRxiv

The SNM1A DNA repair nuclease.

Baddock HT. et al, (2020), DNA Repair (Amst), 95

Genetic and functional insights into CDA-I prevalence and pathogenesis.

Olijnik A-A. et al, (2020), J Med Genet

XPF-ERCC1: Linchpin of DNA crosslink repair

MCHUGH P., (2020), PLoS Genetics

The analysis of DNA interstrand crosslinks and their repair by the modified Comet assay

SWIFT LP. et al, (2020), DNA Electrophoresis: Methods and Protocols., 2119

Optimised oligonucleotide substrates to assay XPF ERCC1 nuclease activity for the discovery of DNA repair inhibitors†

MCHUGH PJ. et al, (2019), Chemical Communications

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.

Doherty W. et al, (2019), Org Biomol Chem

Microhomologies are prevalent at Cas9-induced larger deletions

Owens DDG. et al, (2019), Nucleic Acids Research

Antiviral activity of bone morphogenetic proteins and activins.

Eddowes LA. et al, (2019), Nat Microbiol, 4, 339 - 351

Squaramide-Based 5’-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A

Dürr EM. et al, (2018), ChemistrySelect, 3, 12824 - 12829

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.

Amunugama R. et al, (2018), Cell Rep, 23, 3419 - 3428

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