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Publications

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks

Song W. et al, (2024)

Molecular insights into the stimulation of SNM1A nuclease activity by CSB during interstrand crosslink processing.

Roddan R. et al, (2024)

SNM1A is crucial for efficient repair of complex DNA breaks in human cells.

Swift LP. et al, (2024), Nat Commun, 15

SNM1A is crucial for efficient repair of complex DNA breaks in human cells

MCHUGH P., (2024), Nature Communications

Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target

Bielinski M. et al, (2024), Chemical Science

N-Acyloxymethyl-phthalimides deliver genotoxic formaldehyde to human cells

Emms VL. et al, (2023), Chemical Science

N-Acyloxymethyl-phthalimides deliver genotoxic formaldehyde to human cells

Emms VL. et al, (2023), CHEMICAL SCIENCE, 14, 12498 - 12505

SNM1A (DCLRE1A) is crucial for efficient repair of complex DNA breaks in human cells

McHugh P. et al, (2023)

WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.

Mengoli V. et al, (2022), EMBO J

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock HT. et al, (2022), Nucleic Acids Research

Editorial: Targeting DNA repair and the DNA damage response: Beyond the standard PI3 kinase-like kinases.

Turchi JJ. et al, (2022), Front Oncol, 12

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.

Baddock HT. et al, (2021), Nucleic acids research

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.

Yosaatmadja Y. et al, (2021), Nucleic Acids Res

Neuronal enhancers are hotspots for DNA single-strand break repair.

Wu W. et al, (2021), Nature

The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core

MCHUGH P. and PTCHELKINE D., (2021), Nucleic Acids Research Cancer

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Yosaatmadja Y. et al, (2021)

Repeat expansions confer WRN dependence in microsatellite-unstable cancers.

van Wietmarschen N. et al, (2020), Nature, 586, 292 - 298

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock H. et al, (2020)

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

BADDOCK HT. et al, (2020), bioRxiv

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock H. et al, (2020), bioRxiv

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