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Publications

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

Chen Z. et al, (2022), Cell Death Differ

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.

Chen Z. et al, (2022), Biochem J

The NUCKS1-SKP2-p21/p27 axis controls S phase entry.

Hume S. et al, (2021), Nat Commun, 12

E2F1: Cause and Consequence of DNA Replication Stress

Fouad S. et al, (2021), Frontiers in Molecular Biosciences, 7

The role of E3 ubiquitin ligases in the development and progression of glioblastoma.

Humphreys LM. et al, (2021), Cell Death Differ, 28, 522 - 537

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.

Chen Z. et al, (2020), Open Biol, 10

E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.

Burdova K. et al, (2019), EMBO J, 38

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.

Chen Z. et al, (2019), Structure, 27, 1395 - 1404.e4

Cyclin F-Chk1 synthetic lethality mediated by E2F1 degradation

Burdova K. et al, (2019)

Cullin Ring Ubiquitin Ligases (CRLs) in Cancer: Responses to Ionizing Radiation (IR) Treatment.

Fouad S. et al, (2019), Front Physiol, 10

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression.

Mavrommati I. et al, (2018), Cell Rep, 24, 3404 - 3412

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.

Fung E. et al, (2018), EMBO Rep, 19

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L. et al, (2018), Cell Death Differ, 25, 486 - 541

Two paths to let the replisome go

D'Angiolella V. and Guardavaccaro D., (2017), Cell Death and Differentiation, 24, 1140 - 1141

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication.

Foskolou IP. et al, (2017), Mol Cell, 66, 206 - 220.e9

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.

Raducu M. et al, (2016), EMBO J, 35, 1400 - 1416

WEE1 inhibition selectively kills histone H3K36me3-deficient cancers by dNTP starvation

Pfister SX. et al, (2016), CANCER RESEARCH, 76

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.

Pfister SX. et al, (2015), Cancer Cell, 28, 557 - 568

It is not all about BRCA: Cullin-Ring ubiquitin Ligases in ovarian cancer

Carlucci A. and D'Angiolella V., (2015), British Journal of Cancer, 112, 9 - 13

Beyond survival: fine-tuning GTP production to boost melanoma invasion

D'Angiolella V., (2014), Pigment cell & melanoma research, 27, 159 - 161

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