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Publications

CHK1 inhibition exacerbates replication stress induced by IGF blockade.

Wu X. et al, (2021), Oncogene

DNAPK inhibition preferentially compromises the repair of radiation-induced DNA double-strand breaks in chronically hypoxic tumor cells in xenograft models.

Jiang Y. et al, (2021), Mol Cancer Ther

Olaparib increases the therapeutic index of hemithoracic irradiation compared with hemithoracic irradiation alone in a mouse lung cancer model.

Jiang Y. et al, (2021), Br J Cancer, 124, 1809 - 1819

Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response.

Zhang P. et al, (2021), Cancer Res, 81, 1667 - 1680

Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.

Willoughby CE. et al, (2020), J Clin Invest, 130, 258 - 271

RASSF1A controls tissue stiffness and cancer stem-like cells in lung adenocarcinoma.

Pankova D. et al, (2019), EMBO J

Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer.

Mumin NH. et al, (2019), BMC Cancer, 19

PARP Inhibition Combined With Thoracic Irradiation Exacerbates Esophageal and Skin Toxicity in C57BL6 Mice.

Lourenco LM. et al, (2018), Int J Radiat Oncol Biol Phys, 100, 767 - 775

Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.

Jiang Y. et al, (2016), Int J Radiat Oncol Biol Phys, 95, 772 - 781

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.

Pfister SX. et al, (2015), Cancer Cell, 28, 557 - 568

Acute vascular response to cediranib treatment in human non-small-cell lung cancer xenografts with different tumour stromal architecture.

Jiang Y. et al, (2015), Lung Cancer, 90, 191 - 198

Vascular endothelial growth factor directly stimulates tumour cell proliferation in non-small cell lung cancer.

Devery AM. et al, (2015), Int J Oncol, 47, 849 - 856

Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells.

Bokobza SM. et al, (2014), Oncotarget, 5, 4765 - 4778

Short-course treatment with gefitinib enhances curative potential of radiation therapy in a mouse model of human non-small cell lung cancer.

Bokobza SM. et al, (2014), Int J Radiat Oncol Biol Phys, 88, 947 - 954

Replication stress and chromatin context link ATM activation to a role in DNA replication.

Olcina MM. et al, (2013), Mol Cell, 52, 758 - 766

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

Olcina MM. et al, (2013), Molecular Cell

Sickness behaviour is induced by a peripheral CXC-chemokine also expressed in multiple sclerosis and EAE.

Campbell SJ. et al, (2010), Brain Behav Immun, 24, 738 - 746

Comparison of MRI signatures in pattern I and II multiple sclerosis models.

Serres S. et al, (2009), NMR Biomed, 22, 1014 - 1024

Systemic inflammatory response reactivates immune-mediated lesions in rat brain.

Serres S. et al, (2009), J Neurosci, 29, 4820 - 4828

Inhibition of peripheral TNF can block the malaise associated with CNS inflammatory diseases.

Jiang Y. et al, (2008), Neurobiol Dis, 32, 125 - 132

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