Cell and Molecular Oncology
2004 - Identified the Hippo signalling pathway in humans. Science
2007 - Reported the first evidence for tumour suppression via Lats1 phosphorylation of YAP. Mol Cell
2014 - Demonstrated regulatory control of CDK2 and BRCA2 in response to genomic stress. Nat Cell Biol
2015 - Identified epigenetic mediated selection of alternative promoters as a mechanism of cell phenotype. Curr Biol
2018-2019 - Three consecutive EMBO J papers outlined a role for hippo signalling in regulation of chromatin at the nuclear envelope and responsive to mechanical force.
Mechanotransduction mediated control of epigenetics and cell phenotype.
Role of Hippo signalling at the nuclear envelope in immune cell populations.
Immunology of emerging pancreatic cancer lesions.
Targeting the immunosuppressive microenvironment in pancreatic cancer.
Radiation induced 'vaccination' to establish tumour control in PDAC.
Monitoring patient tumour immune responses ex-vivo in tumour explants
Prof. Tim Elliott https://www.oriel.ox.ac.uk/people/professor-tim-elliott
Dr. Marco Fritzche https://www.kennedy.ox.ac.uk/team/marco-fritzsche
Prof. Cathy Ye https://eng.ox.ac.uk/people/cathy-ye/