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O'NEILL GROUP

Cell and Molecular Oncology

Recent discoveries -SMAD4 driven expression of TET2 is responsible for 5hmc marking of GATA6, GATA6 expression and PDAC subtypes.
Recent Discovery - SMAD4 driven expression of TET2 is responsible for 5hmc marking of GATA6, GATA6 expression and PDAC subtypes.

Key Discoveries 

2004                 - Identified the Hippo signalling pathway in humans. Science

2007                 - Reported the first evidence for tumour suppression via Lats1 phosphorylation of YAP.  Mol Cell

2014                - Demonstrated regulatory control of CDK2 and BRCA2 in response to genomic stress. Nat Cell Biol

2015                - Identified epigenetic mediated selection of alternative promoters as a mechanism of cell phenotype. Curr Biol

2018-2019 - Three consecutive EMBO J papers outlined a role for hippo signalling in regulation of chromatin at the nuclear envelope and responsive to mechanical force.   

 

Overview

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Current Projects 

Mechanotransduction mediated control of epigenetics and cell phenotype.

Role of Hippo signalling at the nuclear envelope in immune cell populations. 

Immunology of emerging pancreatic cancer lesions.

Targeting the immunosuppressive microenvironment in pancreatic cancer. 

Radiation induced 'vaccination' to establish tumour control in PDAC. 

Monitoring patient tumour immune responses ex-vivo in tumour explants 

 

Collaborators

Prof. Tim Elliott              https://www.oriel.ox.ac.uk/people/professor-tim-elliott

Dr. Marco Fritzche       https://www.kennedy.ox.ac.uk/team/marco-fritzsche

Prof. Cathy Ye                  https://eng.ox.ac.uk/people/cathy-ye/

 Industry Links

Oxford BioMedica

Epicombi.ai

 

Current positions

 

Lead Principal Investigator

RESEARCH THEMES

Tumour Immunology

Tumour Microenvironment

DNA Damage & Repair

Selected Publications

More publications

Selected publications

Related research themes

Tumour Immunology
Tumour Immunology
Understanding how to manipulate a tumour's microenvironment and how can use this understanding for therapeutic gain.
Tumour Microenvironment

Understanding how to manipulate a tumour's ...

DNA Damage & Repair
DNA Damage & Repair