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Radiation Biophysics: SARRP Image guided pre-clinical irradiator

Enabling precision irradiation with sub-millimetre accuracy from variable beam direction after treatment planning

Imaging is performed using cone beam CT prior to targeting and irradiating with sub-millimetre accuracy from a number of angles (or continuous rotation) after treatment planning. The addition of a shutter now allows breathing gating to minimise the effect of organ movement during dose delivery and co-registration of images between treatment modalities allows targeting of sites not visible on CT. MRI guided radiotherapy is also possible.

SARRP system

 

Selected publications

  • Verhaegen et al (2018) Technology for Precision Small Animal Radiotherapy Research: optimal use and challenges, Radiotherapy and Oncology. 126, 471-478 [PMID: 29269093]
  • Corroyer-Dulmont et al (2017) Improved outcome of 131I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma.Radiother. Oncol. 124, 488–495 [PMID: 28595752]
  • Hill et al (2017) The Development of Technology for Effective Respiratory-Gated Irradiation Using an Image-Guided Small Animal Irradiator. Radiat. Res. 188, 247-263 [PMID: 28715250].
  • Kersemans et al (2017) An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse.PLoS One. 12(4):e0176693[PMID: 28453537]
  • Hill and Vojnovic (2017) Implications of respiratory motion for small animal image-guided radiotherapy. Br. J. Radiol.  90, 20160482. (2017) [PMID: 27384471]