Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Radiation Biophysics: Ultrasoft X-ray sources

Capable of producing a range of characteristic ultrasoft X-rays: CK (0.28keV), AlK (1.49keV), CuL (0.96keV) & TiK (4.55keV) with dose rates up to ~50 Gy min-1.

Used originally to study the variation in RBE as a function of electron energy. The low energy electrons track-ends produced are similar to those produced by all low-LET radiation and are believed to dominate the biological effect due to their increased effectiveness. Can also be used to irradiate cells with 1 mm wide stripes of x-rays for DNA damage induction and repair studies.

 

Ultrasoft x-ray stripe papers

  • Reynolds et al (2012) The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage. Nucleic Acids Res. 40, 10821-31 [PMID: 23012265]
  • Cornelissen et al (2011) Imaging DNA damage in vivo using γH2AX-targeted immunoconjugates, Cancer Res. 71, 4539-4549 [PMID: 21586614]
  • Bauerschmidt et al (2011) Cohesin Phosphorylation and mobility of SMC1 at ionizing radiation induced DNA double strand breaks in human cells, Exp. Cell Res. 317, 330-337 [PMID: 21056556]
  • Tambini et al (2010) The importance of xrcc2 in rad51-relate DNA damage repair, DNA Repair 9, 517-525  [PMID: 20189471].
  • Bauerschmidt et al (2010) Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin, Nucleic Acids Research, 38, 477-487 [PMID: 19906707]
  • Badie et al (2009) RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation, J. Cell Biol. 185, 587-600 [PMID: 19451272]