Contact information
RESEARCH THEMES
Immunology (Collaborator)
Tumour Microenvironment (Collaborator)
Translational Research (Collaborator)
Alistair Easton
BSc, MBChB, PhD, FRCPath
Senior Clinical Researcher
RESEARCH SUMMARY
Investigating the effects of conventional chemo-radiotherapy on the immune infiltrate in neuroblastoma and the biology of cancer-associated gangliosides relating to their role in tumourogenesis and as a target for immunotherapy
BIOGRAPHY
Alistair studied Medicine at The University of Glasgow and completed an intercalated BSc in Immunology during his undergraduate studies. He trained as a clinical pathologist in the West of Scotland Training School, based at the Western Infirmary, the Royal Infirmary and the Queen Elizabeth University Hospitals in Glasgow. During this training he was awarded a Pathological Society Centenary Clinical Fellowship to complete a PhD in autoimmunity and pathogen ganglioside mimicry in Guillain Barre Syndrome, supervised by Prof Hugh Willison, Dr Carl Goodyear and Prof Allan Mowat, at The University of Glasgow.
In 2014, following completion of his specialist training, he was appointed as Associate Professor and Honorary Consultant at the University of Southampton, where his research interests included tumour immunology, tumour glycosylation and neuroblastoma. In 2019 he was appointed to his current post as a Senior Clinical Researcher at the Department of Oncology.
Recent publications
Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation.
Journal article
Estephan H. et al, (2025), EMBO J, 44, 903 - 922
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.
Journal article
Beach C. et al, (2023), J Clin Invest, 133
Immune characterization of pre-clinical murine models of neuroblastoma.
Journal article
Webb ER. et al, (2020), Sci Rep, 10
Immune responses in pancreatic cancer may be restricted by prevalence of activated regulatory T-cells, dysfunctional and senescent T-cells
Working paper
EASTON A. et al, (2020), Cancer Discovery
IL-1-mediated remodelling of the stromal-neutrophil landscape is associated with non-response to therapy in a subset of inflammatory bowel disease patients
Working paper
EASTON A. et al, (2020), Cell