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Precision Diagnostics


Chronic Lymphocytic Leukaemia

Non-invasive prenatal diagnosis

Anna Schuh

Director of Molecular Diagnostics

  • Honorary Consultant Haematologist

Research Summary

The aim of our research is to identify molecular-based disease classifiers using clinical omics to underpin precision medicine approaches to be used for the selection of patients for the appropriate therapy.


Professor Schuh has participated as a principal or chief investigator in over 30 early or late phase clinical trials  in chronic lymphocytic leukaemia. 

A number of these led to NICE approvals and have changed clinical practice for patients in the UK and worldwide. As a result, she was recently appointed as the Chair of Chronic Lymphocytic Leukaemia Research in the UK by the National Cancer Research Institute. In addition to other national and international roles, she has also chaired the UK CLL Forum from 2016 to 2019 that promotes training and education, and she led the UK's guidelines writing group for CLL Therapy on behalf of the British Society of Haematology. 

Her life-long research interest has been with the development, evaluation and implementation of new technologies for Precision Diagnostics in particular genomics. Her group published the first ever longitudinal study of the changes in the genomic landscape of patients undergoing treatment for leukaemia. More recently, her group has been focussing on identifying novel biomarkers for early detection of B-cell malignancies from  liquid biopsies.

He group has developed and clinically validated a method for non-invasive prenatal diagnosis of autosomal recessive disorders using haemoglobinopathies as a model.

She was appointed as the Director of Molecular Diagnostics by the University of Oxford in 2014. She served as the Clinical Lead for the Oxford Genomics Medicine Centre from 2014 to 2017 and has led the Genomics England Clinical Interpretation Partnership for haematological malignancies. 

She is also the Co-director of the University's online part-time Master's Programme in Precision Cancer Medicine.

Professor Schuh has received grants from the NIHR, Wellcome Trust, Technology Strategy Board (now Innovate UK), Cancer Research UK and Bloodwise and she has authored or co-authored over 80 peer-reviewed publications in the last five years.



Niamh Appleby, Health Education England/ Genomics England Genomic Medicine Fellow
David Bruce, Clinical Research Fellow
Adam Burns, Post-doctoral Researcher
Dr Anthony Cutts, Postdoctoral Researcher
Helene Dreau, MSc. Principal Clinical Scientist / Head of the NGS Core Facilities (Clinical).
Laura del Carmen Lopez Pascua, Clinical Scientist with Bioinformatics
Kate Ridout, High-throughput Sequencing Bioinformatician
Dimitrios V. Vavoulis, High-throughput Bioinformatician

Key publications

Recent publications

More publications