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Francesca Buffa

DPhil


Associate Professor

  • Principal Investigator, Cancer Research UK and European Research Council
  • Group Leader, Computational Biology and Integrative Genomics
  • Academic Lead for Bioinformatics

Research Summary

Francesca is a computational biologist and mathematician whose research focuses on system medicine approaches that help us understand cancer as a complex system.

Key to this work is the development and application of advanced statistical and mathematical modelling approaches,  and machine learning of large multi-omic and functional datasets.

Francesca is funded by Cancer Reseach UK and the European Research Council to investigate how cancer cells re-wire their molecular networks to adapt to a heterogeneous and dynamic tumour microenvironment.

Her lab develops multi-omic cancer classifiers and executable cancer models that enable in-silico experimentation to identify likely resistance mechanisms, predict effective drug combinations, and identify strategies for cancers that are currently incurable.

Biography

After a Masters Degree in Theoretical Physics from the University of Turin, Francesca completed her PhD in Physics and Mathematical Modelling at the Institute of Cancer Research, University of London. She then undertook a postdoctoral research fellowship in Mathematical Modelling and Biostatistics at the Gray Cancer Institute, London, before joining the Medical Sciences Division, University of Oxford, first as a postdoctoral research fellow in Bioinformatics / Biostatistics, then as Group Leader of Computational Biology and Integrative Genomics.

In addition to her research work, she teaches at national and international Masters Courses and Advanced Schools, is a member of national and international panels, including REF-2021, and acts as bioinformatics and biostatistics advisor for genomics clinical research studies.

She authored over 130 publications, several in high impact journals, and she is the recipient of a Cancer Research UK programme and a European Research Council consolidator award.

Group Members

Alessandro Barberis, Postdoctoral Researcher
Philip Charlton, Clinical Research Training Fellow
Jagat Chauhan, Postdoctoral Researcher (based in Oxford Ludwig Institute)
Wei-Chen Cheng, Postdoctoral Researcher
Yueachan Chi, DPhil Student
Matteo Di Giovannantonio, DPhil Student
Ava Van Ess, DPhil Student
Giovanna Granata, Postdoctoral Researcher
Joachim Hagel, DPhil Student
Ben Harris, Clinical Research Training Fellow
Fiona Hartley, DPhil student
Sakura Maezono, DPhil Student (based in Tsukuba University, Japan)
Ana Miar Cuervo, Postdoctoral Researcher
Dawn O'Reilly, Postdoctoral Researcher
Jayathilake Pahala Gedara, Postdoctoral Researcher
Clara Pavillet, DPhil Student
Karen Sayal, DPhil Student
Charalampos Triantafyllidis, Postdoctoral Researcher
Pedro Victori, DPhil Student