Ignacio Torrecilla
PhD
Senior Postdoctoral Research Scientist
Proteostasis in DNA repair
RESEARCH SUMMARY
My research interest is in identifying key molecular events promoting DNA replication and DNA repair, in particular those related to cancer and the response to radiotherapy. Specifically, I investigate how the p97/VCP-ubiquitin system and associated regulatory phenomena conduct cellular adaptations upon DNA damage. Our research uncovers molecular features associated to tumour survival and radiosensitivity, with the ultimate goal of implementing translational therapeutics.
BIOGRAPHY
Ignacio holds a BSc in Chemistry and received his PhD degree in Biochemistry (University Autonoma of Madrid, Spain) with a Thesis on intracellular signalling. He then joined the CPP Department at University of Leicester (UK) to specialize in signal transduction from GPCRs, before moving on to the biotechnology sector. While in industry, he worked extensively on cell metabolism and immunotherapies to tackle medical disorders. In 2013, Ignacio moved to Oxford to begin work at the Department of Oncology in the DNA Damage Response group.
Recent publications
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Isolation and detection of DNA-protein crosslinks in mammalian cells.
Torrecilla I. et al, (2023), Nucleic Acids Res
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SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells.
Na J. et al, (2021), Cell Death Dis, 12
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TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.
Fielden J. et al, (2020), Nat Commun, 11
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The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8.
Singh AN. et al, (2019), EMBO J, 38
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SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.
Halder S. et al, (2019), Nat Commun, 10
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The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks.
Torrecilla I. et al, (2017), Philos Trans R Soc Lond B Biol Sci, 372
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Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.
Vaz B. et al, (2016), Mol Cell, 64, 704 - 719
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Immunological and genetic characterisation of a southern Spain alternaria alternata allergic population
Roca J. et al, (2012), ALLERGY, 67, 249 - 250
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N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons.
Butcher AJ. et al, (2009), J Biol Chem, 284, 17147 - 17156
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Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits.
Cockerill SL. et al, (2007), J Physiol, 581, 479 - 493