Ignacio Torrecilla
PhD
Senior Postdoctoral Research Scientist
Proteostasis in DNA repair
RESEARCH SUMMARY
My research interest is in identifying key molecular events promoting DNA replication and DNA repair, in particular those related to cancer and the response to radiotherapy. Specifically, I investigate how the p97/VCP-ubiquitin system and associated regulatory phenomena conduct cellular adaptations upon DNA damage. Our research uncovers molecular features associated to tumour survival and radiosensitivity, with the ultimate goal of implementing translational therapeutics.
BIOGRAPHY
Ignacio holds a BSc in Chemistry and received his PhD degree in Biochemistry (University Autonoma of Madrid, Spain) with a Thesis on intracellular signalling. He then joined the CPP Department at University of Leicester (UK) to specialize in signal transduction from GPCRs, before moving on to the biotechnology sector. While in industry, he worked extensively on cell metabolism and immunotherapies to tackle medical disorders. In 2013, Ignacio moved to Oxford to begin work at the Department of Oncology in the DNA Damage Response group.
Recent publications
-
Journal article
Torrecilla I. et al, (2023), Nucleic Acids Res
-
Journal article
Na J. et al, (2021), Cell Death Dis, 12
-
Journal article
Fielden J. et al, (2020), Nat Commun, 11
-
Journal article
Singh AN. et al, (2019), EMBO J, 38
-
Journal article
Halder S. et al, (2019), Nat Commun, 10
-
Journal article
Torrecilla I. et al, (2017), Philos Trans R Soc Lond B Biol Sci, 372
-
Journal article
Vaz B. et al, (2016), Mol Cell, 64, 704 - 719
-
Immunological and genetic characterisation of a southern Spain alternaria alternata allergic population
Conference paper
Roca J. et al, (2012), ALLERGY, 67, 249 - 250
-
Journal article
Butcher AJ. et al, (2009), J Biol Chem, 284, 17147 - 17156
-
Journal article
Cockerill SL. et al, (2007), J Physiol, 581, 479 - 493