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Research groups

Student Project:
Nucleases and helicases as potential cancer targets

It is clear that the acquired genetic changes (vulnerabilities) in tumours can be exploited to treat cancer, increasingly in a manner tailored to individual patients. Defects and alterations in DNA repair pathways are often vital for tumour cell viability and are excellent potential therapeutic targets.

We combine cell biology, cellular genetics (including genome editing) and biochemistry (including cryo-electron microscopy) to provide a detailed understanding of key DNA repair pathways that are targets for cancer prevention and treatment.

Peter McHugh

Professor of Molecular Oncology

Research Summary

We aim to understand how repair of damaged DNA is controlled during chromosome duplication, and why potentially dangerous changes in the behaviour of cells can occur when this process goes wrong. We also hope use this improved knowledge of DNA damage and its repair to improve treatments for cancer.

Biography

Following post-doctoral research at University College London, Peter McHugh was awarded a Royal Society University Research Fellowship in 2001. In 2003 he joined the Oncology Laboratories at the MRC Weatherall Institute of Molecular Medicine, where he now heads the DNA Damage and Repair research group.

He is a regular presenter to CRUK fundraisers, and is a co-organiser of the UK Genome Stability Network Annual meeting and of the FEBS Nucleotide Excision Repair and Interstrand Crosslink repair meeting.

GROUP MEMBERS

Sanja Brolih, DPhil Student (MRC)
Abimael Cruz-Migoni, Postdoctoral Researcher (MRC)
Jennifer Gurnett, Postdoctoral Researcher (MRC)
Matthew Harris, D.Phil Student (Wellcome, with Yang Shi and Chris Schofield)
Lucy Henderson, D.Phil Student (Wellcome)
William Nathan, D.Phil Student (NIH-OxCam, with Andre Nussenzweig)
Malitha Ratnaweera, D. Phil Student (MRC)
Lonnie Swift, Postdoctoral Researcher (CR-UK)