Professor of Molecular Oncology
We aim to understand how repair of damaged DNA is controlled during chromosome duplication, and why potentially dangerous changes in the behaviour of cells can occur when this process goes wrong. We also hope use this improved knowledge of DNA damage and its repair to improve treatments for cancer.
Following post-doctoral research at University College London, Peter McHugh was awarded a Royal Society University Research Fellowship in 2001. In 2003 he joined the Oncology Laboratories at the MRC Weatherall Institute of Molecular Medicine, where he now heads the DNA Damage and Repair research group.
He is a regular presenter to CRUK fundraisers, and is a co-organiser of the UK Genome Stability Network Annual meeting and of the FEBS Nucleotide Excision Repair and Interstrand Crosslink repair meeting.
XPF-ERCC1: Linchpin of DNA crosslink repair
MCHUGH P., (2020), PLoS Genetics
The analysis of DNA interstrand crosslinks and their repair by the modified Comet assay
SWIFT LP. et al, (2020), DNA Electrophoresis: Methods and Protocols., 2119
Optimised oligonucleotide substrates to assay XPF ERCC1 nuclease activity for the discovery of DNA repair inhibitors†
MCHUGH PJ. et al, (2019), Chemical Communications
Doherty W. et al, (2019), Org Biomol Chem
Owens DDG. et al, (2019), Nucleic Acids Research