Contact information
+44 (0)1865 222441
+44 (0)1865 222458 (PA)
Rita de Podesta
rita.depodesta@oncology.ox.ac.uk
Research groups
RESEARCH THEMES
Genome Integrity & Epigenetics
Radiation-Immune Interactions (Co-Investigator)
Colleges
D. Phil Supervisory Opportunities
We welcome applications from students interested in pursuing research on the biochemistry, genetics, structural biology and cell biology of DNA repair. Several areas of major focus include:
- Understanding the molecular machines that repair damaged DNA replication forks, and are defective in Fanconi anaemia.
- Inhibiting DNA repair enzymes for the benefit of cancer therapy.
- Understanding how the nucleotide excision repair (NER) pathway processes DNA crosslinks.
- Characterisation of the SARS-Cov-2 nsp14-nsp10 complex: How does this complex maintain viral genome stability and is it druggable?
Peter McHugh
Professor of Molecular Oncology
Research Summary
We aim to understand how repair of damaged DNA is controlled during chromosome duplication, and why potentially dangerous changes in the behaviour of cells can occur when this process goes wrong. We also hope use this improved knowledge of DNA damage and its repair to improve treatments for cancer.
Biography
Following post-doctoral research at University College London, Peter McHugh was awarded a Royal Society University Research Fellowship in 2001. In 2003 he joined the Oncology Laboratories at the MRC Weatherall Institute of Molecular Medicine, where he now heads the DNA Damage and Repair research group.
He is a regular presenter to CRUK fundraisers, and is a co-organiser of the UK Genome Stability Network Annual meeting and of the FEBS Nucleotide Excision Repair and Interstrand Crosslink repair meeting.
GROUP MEMBERS
Recent publications
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Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition
Journal article
Yosaatmadja Y. et al, (2021)
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Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
Journal article
van Wietmarschen N. et al, (2020), Nature, 586, 292 - 298
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Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
Baddock HT. et al, (2020)
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Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
Baddock H. et al, (2020)
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The SNM1A DNA repair nuclease.
Journal article
Baddock HT. et al, (2020), DNA Repair (Amst), 95