Tess Stanly
Dphil
Postdoctoral Research Scientist
T-cell mechanosignalling
Research Summary
My research focuses on studying nuclear actin, T-cell biology, and mechanotransduction. Exploring the cellular and molecular mechanisms underlying immune responses and mechanical sensing – focusing on the role of RASSF1A and nuclear actin. I have a passion for imaging, bioimaging analysis, specializing in ImageJ for advanced quantitative studies.
Biography
Tess completed their DPhil in Medical Sciences at the WIMM (University of Oxford), focusing on membrane receptor and actin dynamics in lymphatic cells. Following research roles at Oxford and York, centring on receptor mediated signalling and dynamics in MPN (blood cancer), Tess is now a Post-Doctoral Scientist in the Department of Oncology at Oxford, specializing in T-cell mechanotransduction and cancer biology. Their expertise includes advanced imaging, cell biology, and signalling. An experienced mentor and lecturer, they also co-lead MSc Applied Cancer Science module and contribute to cutting-edge research in oncology and immune signalling.
Recent publications
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ATR-hippo drives force signaling to nuclear F-actin and links mechanotransduction to neurological disorders.
Chatzifrangkeskou M. et al, (2025), Sci Adv, 11
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The cortical actin network regulates avidity-dependent binding of hyaluronan by the lymphatic vessel endothelial receptor LYVE-1.
Stanly TA. et al, (2020), J Biol Chem, 295, 5036 - 5050
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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.
Wilmes S. et al, (2020), Science, 367, 643 - 652
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Quantitative Optical Diffraction Tomography Imaging of Mouse Platelets.
Stanly TA. et al, (2020), Front Physiol, 11
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Critical importance of appropriate fixation conditions for faithful imaging of receptor microclusters.
Stanly TA. et al, (2016), Biol Open, 5, 1343 - 1350