Title

Research

Research Groups

DNA Damage and Disease Group

We study the signalling mechanisms cells use to respond to DNA damage and why defects in these...

 
Cancer Therapeutics and mRNA Dysregulation

Investigating post-transcriptional mechanisms that drive cancer behaviour and researching novel...

 
Cancer and Immunogenetics Laboratory

Our major interests are in the fundamental genetics and biology of colorectal cancer and their...

 
Oncological Image Analysis

We develop image analysis methods for quantitative analysis of medical images,...

 
Nucleic Acids Research Group

We design and synthesise chemically modified DNA for diagnostic and therapeutic applications....

 
Computational Biology and Integrative Genomics

We use system biology approaches to search for integrated genomic blueprints that enable us to...

 
Cancer therapeutics, DNA damage and repair laboratory

A major focus of our work is exploring how ATRX prevents normal cells from elongating their...

 
Radiopharmaceuticals and Molecular Imaging Group

We aim to develop new radioisotope-labelled compounds for the imaging of tumour biology.

 
Cell Cycle and Ubiquitin Mediated Proteolysis Group

Our group objective is to identify novel pathways governing cell proliferation, which are...

 
Biochemistry and Regulation of DNA Repair Group

The long-term goal of the Dianov Laboratory is to study the proteins and mechanisms involved in...

 
Novel Clinical Imaging Research Group

Our group focuses on using imaging techniques in small-scale trials with the particular...

 
Tumour Hypoxia Group

We are investigating how tumours survive in conditions which include low oxygen (hypoxia). Our...

 
Hypoxia and Angiogenesis Group

The focus of the group is on tumour angiogenesis and the role of notch signalling, and hypoxia...

 
New Technical Radiotherapy/Advanced Radiation Oncology Group

Personalising gastro-intestinal cancers radiotherapy: the ultimate aim of the research of my...

 
Tumour Radiosensitivity Research Group

Our research focuses on finding new ways of making tumours more sensitive to radiotherapy...

 
Chromosome Integrity Group

The aim or our research is to understand how genome stability is maintained in response to DNA...

 
Adjuvant Colorectal Cancer Group

Delivering the right treatment to the right patient at the right time.

 
DNA Repair in Cancer Treatment Group

We are investigating DNA damage signalling and repair factors in bladder cancer to develop new...

 
Cancer Cell Cycle Group

Research in Nick La Thangue’s group focusses on the mechanisms that give rise to the abnormal...

 
IGF Group

We are studying the role of insulin-like growth factor (IGF) signalling in tumour biology,...

 
Clinical Research Programmes, CRUK/MRC Oxford Institute for Radiation Oncology

We aim to deliver a step change in the effectiveness of radiotherapy through the evaluation of...

 
DNA Damage and Repair Group

We aim to understand how repair of damaged DNA is controlled during chromosome duplication, and...

 
Director, CRUK/MRC Oxford Institute for Radiation Oncology. Molecular Resistance to Treatments Group

Our research links basic science with clinical applications and focuses on understanding the...

 
Head of Department of Oncology. Early Phase Clinical Trials & Melanoma Therapy

Mark Middleton’s research concentrates on development of new cancer drugs and on the treatment...

 
Mechanisms of Metastasis Group

We are interested in the mechanisms underlying the development of metastasis, the spread of...

 

My interests over the years have focussed on the chemistry and biochemical pathways involved in...

 
Cell Signalling Group

Our research aims to understand the cell and molecular biology behind frequent tumour mutations...

 
DNA Damage Response Group

We are interested in the role of the ubiquitin-proteasome system in DNA repair, ageing, cancer...

 
Lung Cancer Research Group

Our group aims to identify novel therapies that target subgroups of lung cancer patients...

 
Oxford Molecular Diagnostics Centre

The aim of our research is to identify molecular-based disease classifiers using clinical omics...

 
Anticancer Viruses and Cancer Vaccines Group

The aim of our research is to design and develop innovative cancer killing viruses and oncolytic...

 
Experimental Neuroimaging Group

Our goals are to identify the role of the inflammatory and metabolic microenvironment in brain...

 
Genome Stability and Tumourigenesis Group

Our research is focused on gaining a greater understanding of how homologous recombination (HR...

 
Experimental Radiation Therapeutics Group

Personalising radiotherapy using functional imaging: we apply functional and molecular imaging...

 
Radiation Therapy Medical Physics Group

Our research group specialises in bringing fundamental physical concepts to enhance everyday...

 
Advanced Technology Development Group

Our work focuses on the application of novel imaging modalities and on the development of...

 

Core Facilities

Graham Brown, Core Leader

The Bioanalysis Core provides support in flow cytometry and in measuring concentrations of small...

 
Francesca Buffa, Academic Lead

We provide expertise in computational biology ranging from applied statistics to computational...

 
Brian Burns, Core Leader

The Clinical Imaging Core supports the development and implementation of advanced imaging...

 
Frank Van den Heuvel, Academic Lead

The Clinical Radiotherapy Core supports the implementation of clinical trials involving novel...

 
Sandie Wellman, Core Leader

The Early Phase Clinical Trials Unit aims to support the translation of research findings in to...

 
Sarah Blagden, Academic Lead

The goal of the Oxford Experimental Cancer Medicine (ECMC) GCP laboratories is to accelerate the...

 
Sean Smart, Core Leader

The Imaging Core provides routine technical support services and operates a programme of...

 
John Prentice, Workshop Manager

The Mechanical Workshop assists numerous scientific groups within the Department and the...

 
Graham Brown, Core Leader

The Microscopy Core aims to provide research groups with imaging technologies to investigate...

 
Sarah Pearson, Trial Management Director

The Oncology Clinical Trials Office (OCTO) provides clinical trial management support to...

 
Rebekka Hueting, Core Leader

The PET Radiochemistry and Radiopharmacy core supports radiochemistry-dependent research...

 
Mark Hill, Core Leader

The Radiation Biophysics Core facilitates radiation research within the department and...

 
About Us
We aim to enhance clinical and basic cancer research in Oxford with the ultimate goal of increasing cancer cure rates.
Research
In Oxford, we have a great wealth of broad-ranging expertise and a powerful network of cancer researchers.
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