Research groups
Tristan Kennedy
PhD
Postdoctoral researcher
Research Summary
My research is focused on the role of chromosomal instability (CIN) in tumourigenesis. Specifically, I am investigating how two protocadherin proteins, FAT1 and FAT4 contribute to CIN in triple-negative breast cancer (TNBC). By identifying these roles, we hope to find novel treatment strategies.
Biography
Tristan completed his PhD in Cancer and Genomic Sciences at the University of Birmingham in 2023 as part of the MRC IMPACT doctoral training programme. During this doctoral work in the group of Professor Mathew Coleman, Tristan investigated the role of a novel hydroxylase enzyme complex in maintaining replication fidelity and genome stability. He subsequently undertook a short postdoctoral position within the Coleman group before joining the Department of Oncology to work with Dr Wei-Ting Lu in January 2026.
Recent publications
Inactivation of a protein hydroxylase complex impairs replication fork restart in cancer and neurodevelopmental disorders
Preprint
Kennedy TJ. et al, (2025)
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5.
Journal article
Brewitz L. et al, (2023), J Med Chem, 66, 10849 - 10865
Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans.
Journal article
Fletcher SC. et al, (2023), J Clin Invest, 133

