Contact information

Email
katherine.vallis@oncology.ox.ac.uk

Telephone
+44 (0)1865 2 25850

Research groups

VALLIS GROUP

Katherine Vallis

Professor of Experimental Radiotherapeutics

Group Leader
Honorary Consultant in Clinical Oncology, Oxford University Hospitals NHS Foundation Trust

Research Summary

Our research focus is on understanding and exploiting the biological effects of external beam ionizing radiation and therapeutic radionuclides in solid tumours (breast, lung, pancreas, oesophageal and colorectal cancers among others).

Biography

Katherine undertook specialist training in Clinical Oncology at the Hammersmith Hospital and doctoral research at Edinburgh University. In 1995 she was appointed as Staff Radiation Oncologist at the Princess Margaret Hospital and Scientist at the Ontario Cancer Institute, Toronto. She returned to the UK in 2006 to join the Oxford Institute for Radiation Oncology and established the Experimental Radiotherapeutics Group.

GROUP MEMBERS

Dongxiao Yang, Postdoctoral Researcher
Hung Lau, Oncology DPhil Student
Viktoria Krol, Oncology MRes student
Yang-Hong Dai, Oncology DPhil Student
Mark Macsuka, Oncology DPhil Student (Clarendon Scholar)
Mia Dobbing, Oncology DPhil Student
Stan Fayn, DPhil Student (NIH OxCam)

Key publications

A novel fast strategy to calculate equieffective doses under different dose rate conditions.

Macsuka MJ. et al, (2025), Med Phys, 52, 3416 - 3427

Theranostics for Neuroblastoma: Making Molecular Radiotherapy Work Better.

Gawne PJ. et al, (2025), J Nucl Med, 66, 490 - 496

Targeting c-MET for Endoscopic Detection of Dysplastic Lesions within Barrett's Esophagus Using EMI-137 Fluorescence Imaging.

Huang Y-J. et al, (2025), Clin Cancer Res, 31, 98 - 109

Deep learning-assisted interactive contouring of lung cancer: Impact on contouring time and consistency.

Trimpl MJ. et al, (2024), Radiother Oncol, 200

Strength in numbers: cell penetrating peptide clusters to build next-generation therapeutics

Reeman J. et al, (2024), Trends in Chemistry, 6, 669 - 683

A Meta-analysis and Meta-regression of Efficacy, Toxicity and Quality of Life Outcomes Following Lutetium-177– and Actinium-225–PSMA Radioligand Therapy in Metastatic Prostate Cancer

Dai Y-H. et al, (2024), European Urology

Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity.

Then CK. et al, (2024), Microbiome, 12

Impact of cyclic changes in pharmacokinetics and absorbed dose in pediatric neuroblastoma patients receiving [177Lu]Lu-DOTATATE.

Malcolm JC. et al, (2022), EJNMMI Phys, 9

Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells.

Tietz O. et al, (2022), Nat Chem, 14, 284 - 293

Combining External Beam Radiation and Radionuclide Therapies: Rationale, Radiobiology, Results and Roadblocks.

Abbott EM. et al, (2021), Clin Oncol (R Coll Radiol), 33, 735 - 743

Recent publications

Cumulative Absorbed Dose and Successive Cyclic Reduction in Absorbed Dose Predict Response to 177Lu-DOTATATE in Neuroendocrine Tumors.

Macsuka MJ. et al, (2026), J Nucl Med

Radiation dose escalation in locally advanced oesophageal cancer: a systematic review and hierarchical Bayesian meta-analysis.

Dai Y-H. et al, (2025), EClinicalMedicine, 87

Targeting c-MET for Endoscopic Detection of Dysplastic Lesions within Barrett's Esophagus Using EMI-137 Fluorescence Imaging.

Huang Y-J. et al, (2025), Clin Cancer Res, 31, 98 - 109

Deep learning-assisted interactive contouring of lung cancer: Impact on contouring time and consistency.

Trimpl MJ. et al, (2024), Radiother Oncol, 200

Strength in numbers: cell penetrating peptide clusters to build next-generation therapeutics

Reeman J. et al, (2024), Trends in Chemistry, 6, 669 - 683

A Meta-analysis and Meta-regression of Efficacy, Toxicity and Quality of Life Outcomes Following Lutetium-177– and Actinium-225–PSMA Radioligand Therapy in Metastatic Prostate Cancer

Dai Y-H. et al, (2024), European Urology

Modular and automated synthesis of oligonucleotide-small molecule conjugates for cathepsin B mediated traceless release of payloads.

Jin C. et al, (2024), RSC Chem Biol, 5, 738 - 744

Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity.

Then CK. et al, (2024), Microbiome, 12

A Review of Ultrasound-Mediated Checkpoint Inhibitor Immunotherapy.

Rivera J. et al, (2024), Ultrasound Med Biol, 50, 1 - 7

Paired Diffusion: Generation of Related, Synthetic PET-CT-Segmentation Scans Using Linked Denoising Diffusion Probabilistic Models.

Bradbury R. et al, (2024), ISBI, 1 - 5

Paired Diffusion: Generation of related, synthetic PET-CT-Segmentation scans using Linked Denoising Diffusion Probabilistic Models.

Bradbury R. et al, (2024), CoRR, abs/2403.17734

Reinforcement Learning for Bandits with Continuous Actions and Large Context Spaces

Duckworth P. et al, (2023), Frontiers in Artificial Intelligence and Applications, 372, 590 - 597

Cancer Informatics for Cancer Centers: Sharing Ideas on How to Build an Artificial Intelligence-Ready Informatics Ecosystem for Radiation Oncology.

Bitterman DS. et al, (2023), JCO Clin Cancer Inform, 7

Impact of cyclic changes in pharmacokinetics and absorbed dose in pediatric neuroblastoma patients receiving [177Lu]Lu-DOTATATE.

Malcolm JC. et al, (2022), EJNMMI Phys, 9

Engineering Enzyme-Cleavable Oligonucleotides by Automated Solid-Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers.

Jin C. et al, (2022), Angew Chem Weinheim Bergstr Ger, 134

Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells.

Tietz O. et al, (2022), Nat Chem, 14, 284 - 293

Combining External Beam Radiation and Radionuclide Therapies: Rationale, Radiobiology, Results and Roadblocks.

Abbott EM. et al, (2021), Clin Oncol (R Coll Radiol), 33, 735 - 743

3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation.

Skaripa-Koukelli I. et al, (2021), Cancer Metab, 9

Oligonucleotide-Functionalized Gold Nanoparticles for Synchronous Telomerase Inhibition, Radiosensitization, and Delivery of Theranostic Radionuclides.

Bavelaar BM. et al, (2021), Mol Pharm, 18, 3820 - 3831

Photoactivatable prodrug for simultaneous release of mertansine and CO along with a BODIPY derivative as a luminescent marker in mitochondria: a proof of concept for NIR image-guided cancer therapy.

Tiwari R. et al, (2020), Chem Sci, 12, 2667 - 2673

The Impact of Radiobiologically Informed Dose Prescription on the Clinical Benefit of 90Y SIRT in Colorectal Cancer Patients.

Abbott EM. et al, (2020), J Nucl Med, 61, 1658 - 1664

Proton vs photon: A model-based approach to patient selection for reduction of cardiac toxicity in locally advanced lung cancer.

Teoh S. et al, (2020), Radiother Oncol, 152, 151 - 162

An 111In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells.

Gill MR. et al, (2020), Chem Sci, 11, 8936 - 8944

An 111In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: Mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells

Gill MR. et al, (2020), Chemical Science, 11, 8936 - 8944

Manganese-free chow, a refined non-invasive solution to reduce gastrointestinal signal for T1-weighted magnetic resonance imaging of the mouse abdomen.

Kersemans V. et al, (2020), Lab Anim, 54, 353 - 364

Assessment of robustness against setup uncertainties using probabilistic scenarios in lung cancer: a comparison of proton with photon therapy.

Teoh S. et al, (2020), Br J Radiol, 93

Metallointercalator [Ru(dppz)2(PIP)]2+ Renders BRCA Wild-Type Triple-Negative Breast Cancer Cells Hypersensitive to PARP Inhibition.

Yusoh NA. et al, (2020), ACS Chem Biol, 15, 378 - 387

Megavoltage Radiosensitization of Gold Nanoparticles on a Glioblastoma Cancer Cell Line Using a Clinical Platform.

Kazmi F. et al, (2020), Int J Mol Sci, 21

Application of artificial intelligence (AI) in Radiotherapy workflow: Paradigm shift in Precision Radiotherapy using Machine Learning.

Boon IS. et al, (2019), Br J Radiol, 92

Megavoltage Radiosensitization of Gold Nanoparticles on Glioblastoma Cancer Cell Line Using a Clinical Platform

Kazmi F. et al, (2019), Preprints 2019

Probing the limits of Q-tag bioconjugation of antibodies.

Marculescu C. et al, (2019), Chem Commun (Camb), 55, 11342 - 11345

Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer Cells.

Jackson MR. et al, (2019), Cancer Res, 79, 4627 - 4637

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