External Seminar: Structure and Mechanisms of LINE-1: an Emerging Biomarker & Cancer Target

Martin Taylor, MD, PhD, Instructor: Structure and Mechanisms of LINE-1: an Emerging Biomarker & Cancer Target

Thursday 7 November 13.00-14.00

ORCRB Room 71A/B/C (in person only)

Hosted by: Associate Professor Eileen Parkes

Dr Taylor received his MD. and PhD from Johns Hopkins University where he studied the role of ghrelin acylation in control of metabolism and its potential as a therapeutic target. He then went on to study the interactions between the LINE-1 transposon and host and the role of LINE-1 in cancer in Boeke and Burns labs. He completed residency in Anatomic Pathology (AP) at Massachusetts General Hospital, where he served as Chief Resident and completed subspecialty training in gastrointestinal (GI) pathology. Thereafter, he began postdoctoral training at the Whitehead Institute / MIT. He joined the faculty of Harvard Medical School as Instructor in Pathology in 2021 and practices clinically as a GI pathologist. Marty has just set up his lab in Brown.

Current research: Marty is studying the structure and function of the LINE-1 ORF2 protein, and the potential utility of LINE-1 ORF1p as a cancer biomarker in tissue and plasma. Marty's career development and research on mTORC2 activation and substrate recognition in growth factor signalling are supported by a K08 award from NIH.