Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Madalena Tarsounas' group have recently published two new papers in EMBO Molecular Medicine and Nature Communications.

The Tarsounas group, Department of Oncology

In Tacconi et al . they discovered that chlorambucil, an alkylating agent in clinical use for the treatment of leukemia, has a high therapeutic potential against BRCA1/2-mutated tumours. Importantly, while being equally effective as cisplatin against this tumour subset, chlorambucil showed significantly lower overall toxicity.

Find the original publication here:

https://www.embopress.org/lookup/doi/10.15252/emmm.201809982

 

In Reisländer et al. they demonstrated that loss of BRCA2 leads to activation of the cGAS-STING pathway which results in a cell-intrinsic type I interferon response. Importantly, this innate immune response in BRCA2-deficient cells is potentiated by treatment with PARP inhibitors.

Find the original publication here:

https://www.nature.com/articles/s41467-019-11048-5

 

Similar stories

Hidden lung damage from COVID-19 revealed in new study

Research Translational Research

Early findings from a study into longer-term damage amongst patients recovering from COVID-19 suggest that the use of cutting-edge scanning techniques may detect previously unseen lung damage.

Oxfordshire-based SCAN pathway wins BMJ award

Innovation Research

A pathway designed to investigate individuals with non-specific but concerning symptoms of cancer wins the BMJ Awards 2020 Cancer Care Team of the Year.

Tackling the serious side effects of cancer treatment in an ageing population

Publication Research

Prof. Anne Kiltie and her team discuss their important work into the effects of radiosensitisation on ageing cancer patients with the CRUK Science Blog.

New digital classification method using AI developed for colorectal cancer

Artificial Intelligence Research Translational Research

Understanding the molecular subtype of a cancer is becoming an importance part of the diagnostic process as it helps a doctor better understand a patient’s prognosis, determine the best course of action for treatment and helps researchers devise new, more-efficient, precision therapies.

The CNIO creates a collaborative platform to streamline brain metastasis research

Research

Professor Nicola Sibson has been involved in the CNIO platform to compile a repository for brain metastasis cell lines.

Virtual teaching with AimHi

General Outreach Research

One of our scientists, Dr Hannah Bolland, has become a virtual teacher, connecting school students with science.