Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Madalena Tarsounas' group have recently published two new papers in EMBO Molecular Medicine and Nature Communications.

The Tarsounas group, Department of Oncology

In Tacconi et al . they discovered that chlorambucil, an alkylating agent in clinical use for the treatment of leukemia, has a high therapeutic potential against BRCA1/2-mutated tumours. Importantly, while being equally effective as cisplatin against this tumour subset, chlorambucil showed significantly lower overall toxicity.

Find the original publication here:

https://www.embopress.org/lookup/doi/10.15252/emmm.201809982

 

In Reisländer et al. they demonstrated that loss of BRCA2 leads to activation of the cGAS-STING pathway which results in a cell-intrinsic type I interferon response. Importantly, this innate immune response in BRCA2-deficient cells is potentiated by treatment with PARP inhibitors.

Find the original publication here:

https://www.nature.com/articles/s41467-019-11048-5

 

Similar stories

Festive Science Image Competition Winners

Winners of the Medical Research Foundation's second Festive Science Image Competition, run in partnership with the Medical Research Council (MRC), have been announced today.

Robert Watson Awarded ACP McElwain and Presidents Prize

Dr Robert Watson has won one of three McElwain and President's Prizes from the Association of Cancer Physicians for his DPhil work undertaken with Professor Ben Fairfax.

Prof Anna Schuh launches first private specialised haematology clinic and laboratory in sub-Saharan Africa.

SerenOx Africa aims to address diagnostic gaps for common blood disorders through a testing facility for key underserved patient populations in Tanzania. This facility will also aim to provide early cancer detection for high-risk patients.

Professor Eileen Parkes appointed to lead Oxford’s Experimental Cancer Medicine Centre

Eileen Parkes, Associate Professor in Innate Tumour Immunology in the Department of Oncology, will lead the expansion of the centre’s programmes in early drug development and biomarker research.

Machine Learning Predicts SETD2 Mutation Status with Unprecedented Accuracy using DNA methylation

In a pan-cancer analysis spanning 24 different cancer type, researchers shed light on the critical role of SETD2 in tumourigenesis.

Oxford to launch UK’s first trials unit dedicated to conducting precision prevention and early detection studies

Oxford researchers have been given a £1 million boost to support their strategy of developing cancer prevention treatments and early diagnostic tools for people at high risk of cancer.